142598-83-2

Basic information

• Product Name: 5-CHLORO-3-(4-NITROPHENYL)ISOXAZOLE
• Synonyms: 5-CHLORO-3-(4-NITROPHENYL)ISOXAZOLE
• CAS NO: 142598-83-2
• Molecular Formula: C₉H₅ClN₂O₃
• Molecular Weight: 0
• Mol File: 142598-83-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-CHLORO-3-(4-NITROPHENYL)ISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-3-(4-NITROPHENYL)ISOXAZOLE(142598-83-2)
• EPA Substance Registry System: 5-CHLORO-3-(4-NITROPHENYL)ISOXAZOLE(142598-83-2)

Safety Data

• Hazardous Substances Data: 142598-83-2(Hazardous Substances Data)

Upstream product

• 31913-36-7 2-(4-nitrophenyl)-1,1-dichlorocyclopropane 
• 2415-80-7 1,1-dichloro-2-phenylcyclopropane 

Downstream Products

• 25755-90-2 5-methoxy-3-(4-nitrophenyl)isoxazole 

Relevant articles and documents

Nitration of 1,1-dihalo-2-(4'-nitrophenyl)cyclopropanes: New method to prepare isoxazole

5-Halo-3-(4'-nitrophenyl)isoxazoles were prepared from the nitration of 1,1-dihalo-2-(4'-nitrophenyl)cyclopropanes in good yields.

Transformations of gem-dichloroarylcyclopropanes in the reaction with NOCl·2SO3. Synthesis of 3-aryl-5-chloroisoxazoles

Nitrosation with complex NOCl·2SO3 of gem-dichloroarylcyclopropanes containing acceptor substituents in the aromatic ring proceeded chemo- and regioselectively affording 3-aryl-5-chloroisoxazoles in high yields. The presence of donor substituents complicated the reaction by the occurrence of competing processes.

Nitration of 2-Aryl-1,1-dichlorocyclopropanes

A series of 2-aryl-1,1-dichlorocyclopropanes were nitrated with a mixture of nitric acid and sulfuric acid.The results suggest that an electron-withdrawing group on the phenyl ring and gem-dihalogens on the cyclopropane ring are essential for isoxazole formation.