142602-53-7

Basic information

• Product Name: 2-Propenoic acid, 3-(2-methoxyphenyl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (Z)-
• CAS NO: 142602-53-7
• Molecular Formula: C19H19NO5
• Molecular Weight: 341.364
• Mol File: 142602-53-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(2-methoxyphenyl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(2-methoxyphenyl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (Z)-(142602-53-7)
• EPA Substance Registry System: 2-Propenoic acid, 3-(2-methoxyphenyl)-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (Z)-(142602-53-7)

Safety Data

• Hazardous Substances Data: 142602-53-7(Hazardous Substances Data)

Upstream product

• 100945-15-1 N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester 
• 135-02-4 ortho-anisaldehyde 

Relevant articles and documents

Convenient preparative method for synthesis of methyl (Z)-3-aryl-2-(carbobenzoxyamino)acrylates by Wittig-Horner reaction with the use of Et3N as a base

The Wittig-Horner reaction of CbzNHCH(CO2Me)P(O)(OMe)2 (1) with ArCHO (2) in the presence of Et3N as a base affords methyl (Z)-3-aryl-2-(carbobenzoxyamino)acrylates (3) with high degrees of diastereoselectivity (Z)/(E) > 10:1.One recrystallization of the crude product is sufficient to obtain isomerically and chemically pure (Z)-3. - Keywords: α,β-dehydro-α-amino acids; Wittig-Horner reaction; diastereoselectivity; triethylamine; (Z)-3-aryl-2-(carbobenzoxyamino)acrylates; synthesis.