1426082-58-7Relevant articles and documents
Organocatalytic C-H bond arylation of aldehydes to bis-heteroaryl ketones
Toh, Qiao Yan,McNally, Andrew,Vera, Silvia,Erdmann, Nico,Gaunt, Matthew J.
, p. 3772 - 3775 (2013)
An organocatalytic aldehyde C-H bond arylation process for the synthesis of complex heteroaryl ketones has been developed. By exploiting the inherent electrophilicity of diaryliodonium salts, we have found that a commercial N-heterocyclic carbene catalyst promotes the union of heteroaryl aldehydes and these heteroaromatic electrophile equivalents in good yields. This straightforward catalytic protocol offers access to ketones bearing a diverse array of arene and heteroarene substituents that can subsequently be converted into molecules displaying structural motifs commonly found in medicinal agents.
