1426097-45-1

Basic information

• Product Name: 6-chloro-2-phenyl-1-p-toluenesulfonylbenzimidazole
• Synonyms: 6-chloro-2-phenyl-1-p-toluenesulfonylbenzimidazole
• CAS NO: 1426097-45-1
• Molecular Weight: 382.87
• Mol File: 1426097-45-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-chloro-2-phenyl-1-p-toluenesulfonylbenzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-phenyl-1-p-toluenesulfonylbenzimidazole(1426097-45-1)
• EPA Substance Registry System: 6-chloro-2-phenyl-1-p-toluenesulfonylbenzimidazole(1426097-45-1)

Safety Data

• Hazardous Substances Data: 1426097-45-1(Hazardous Substances Data)

Upstream product

• 941-55-9 4-toluenesulfonyl azide 
• 7035-69-0 N-(4-chlorophenyl)benzamidine 
• 1538-98-3 p-tosyldiazomethane 
• 1426097-42-8 C₂₀H₁₇ClN₂O₂S 

Relevant articles and documents

Preparation method of 1,2-substituted benzimidazole derivative

The invention discloses a preparation method of a 1,2-substituted benzimidazole derivative. The preparation method comprises the following steps: uniformly mixing an N-phenyl amidine derivative, a nitrine derivative, an acid compound, a catalyst, a metal salt and an organic solvent; and performing a reaction for 10-13h at 78-82 DEG C in an air atmosphere to obtain the 1,2-substituted benzimidazole derivative. The method disclosed by the invention can be used for synthesizing a compound with a benzimidazole derivative framework, which cannot be synthesized by other methods. The used raw materials are easily available, and the preparation method is high in yield, mild in reaction condition, wide in primer range, small in catalyst dosage, strong in reaction specificity and simple and green in post-treatment, and the utilization ratio of atoms reaches up to 90% and above.

Iodobenzene catalyzed C-H amination of N-substituted amidines using m-chloroperbenzoic acid

The oxidative C-H amination of N″-aryl-N′-tosyl/N′- methylsulfonylamidines and N,N′-bis(aryl)amidines has been accomplished using iodobenzene as a catalyst to furnish 1,2-disubstituted benzimidazoles in the presence of mCPBA as a terminal oxidant at room temperature. The reaction is general, and the target products can be obtained in moderate to high yields.