1426231-98-2

Basic information

• Product Name: C₂₃H₂₆Cl₂N₄O₂S
• Synonyms: C₂₃H₂₆Cl₂N₄O₂S
• CAS NO: 1426231-98-2
• Molecular Weight: 493.457
• Mol File: 1426231-98-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₆Cl₂N₄O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₆Cl₂N₄O₂S(1426231-98-2)
• EPA Substance Registry System: C₂₃H₂₆Cl₂N₄O₂S(1426231-98-2)

Safety Data

• Hazardous Substances Data: 1426231-98-2(Hazardous Substances Data)

Upstream product

• 5332-24-1 3-bromoquinoline 
• 76076-35-2 3-mercaptoquinoline 
• 159182-40-8 quinoline-3-sulfonyl chloride 
• 189061-44-7 4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butylamine 

Relevant articles and documents

Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT 1A/5-HT2A/5-HT7 and dopamine D 2/D3 receptors

A series of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole was synthesized to explore the influence of two structural features-replacement of ether/amide moiety with sulfonamide one, and localization of a sulfonamide group in the azine moiety. In contrast to aripiprazole, compound 33 (N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl) quinoline-7-sulfonamide) and 39 (N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl) butyl)isoquinoline-3-sulfonamide) displaying multireceptor 5-HT 1A/5-HT2A/5-HT7/D2/D3 profile, and behaving as 5-HT1A agonists, D2 partial agonists, and 5-HT2A/5-HT7 antagonists, produced significant antidepressant activity in FST in mice. On the other hand, their 4-isoquinolinyl analog 40 (N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl) isoquinoline-4-sulfonamide), with similar receptor binding and functional profile, additionally displayed remarkable antipsychotic properties in the MK-801-induced hyperlocomotor activity in mice.