1426683-32-0

Basic information

• Product Name: methyl 2-[methyl(methylsulfonyl)amino]-5-nitrobenzoate
• Synonyms: methyl 2-[methyl(methylsulfonyl)amino]-5-nitrobenzoate
• CAS NO: 1426683-32-0
• Molecular Weight: 288.281
• Mol File: 1426683-32-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-[methyl(methylsulfonyl)amino]-5-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-[methyl(methylsulfonyl)amino]-5-nitrobenzoate(1426683-32-0)
• EPA Substance Registry System: methyl 2-[methyl(methylsulfonyl)amino]-5-nitrobenzoate(1426683-32-0)

Safety Data

• Hazardous Substances Data: 1426683-32-0(Hazardous Substances Data)

Upstream product

• 1184-85-6 N-methylmethane sulphonamide 
• 2965-22-2 methyl 2-fluoro-5-nitro-benzoate 

Downstream Products

• 1426683-51-3 C₁₈H₁₇FN₄O₂S 
• 1426683-52-4 C₁₈H₁₇BrN₄O₂S 
• 1426683-53-5 N-(4-tert-butylbenzyl)-1,5-dimethyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-amine 4,4-dioxide 

Relevant articles and documents

Structure-based discovery of cellular-active allosteric inhibitors of FAK

In order to develop potent and selective focal adhesion kinase (FAK) inhibitors, synthetic studies on pyrazolo[4,3-c][2,1]benzothiazines targeted for the FAK allosteric site were carried out. Based on the X-ray structural analysis of the co-crystal of the lead compound, 8-(4-ethylphenyl)-5-methyl-1,5- dihydropyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide 1 with FAK, we designed and prepared 1,5-dimethyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin derivatives which selectively inhibited kinase activity of FAK without affecting seven other kinases. The optimized compound, N-(4-tert-butylbenzyl)-1,5-dimethyl-1,5- dihydropyrazolo[4,3-c][2,1]benzothiazin-8-amine 4,4-dioxide 30 possessed significant FAK kinase inhibitory activities both in cell-free (IC50 = 0.64 μM) and in cellular assays (IC50 = 7.1 μM). These results clearly demonstrated a potential of FAK allosteric inhibitors as antitumor agents.