1426804-74-1Relevant articles and documents
From RORλt Agonist to Two Types of RORλt Inverse Agonists
Wang, Yonghui,Cai, Wei,Tang, Ting,Liu, Qian,Yang, Ting,Yang, Liuqing,Ma, Yingli,Zhang, Guifeng,Huang, Yafei,Song, Xiaoxia,Orband-Miller, Lisa A.,Wu, Qianqian,Zhou, Ling,Xiang, Zhijun,Xiang, Jia-Ning,Leung, Stewart,Shao, Liming,Lin, Xichen,Lobera, Mercedes,Ren, Feng
, p. 120 - 124 (2018)
Biaryl amides as new RORλt modulators were discovered. The crystal structure of biaryl amide agonist 6 in complex with RORλt ligand binding domain (LBD) was resolved, and both "short" and "long" inverse agonists were obtained by removing from 6 or adding
