1426939-44-7 Usage
Description
C25H36O5, also known as simvastatin lactone, is an oxidation product of simvastatin (S485000) derived from the use of cetyltrimethylammonium dichromate. It is a complex organic molecule with a molecular formula indicating a high carbon content, which is characteristic of many pharmaceutical compounds and organic compounds in general.
Uses
Used in Pharmaceutical Industry:
C25H36O5 is used as an intermediate compound for the synthesis of various pharmaceutical products. Its role in the production process is crucial due to its ability to be further modified or used as a building block for creating more complex and effective drugs.
Used in Research and Development:
In the field of research and development, C25H36O5 serves as a valuable compound for studying the properties and behavior of simvastatin and its derivatives. This can lead to the discovery of new applications and improvements in drug design, potentially benefiting various therapeutic areas.
Used in Quality Control and Analysis:
C25H36O5 is also utilized in quality control processes to ensure the purity and efficacy of simvastatin and related products. By analyzing the presence and concentration of this compound, researchers and quality control specialists can assess the quality of the final product and make necessary adjustments during the manufacturing process.
Check Digit Verification of cas no
The CAS Registry Mumber 1426939-44-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,6,9,3 and 9 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1426939-44:
(9*1)+(8*4)+(7*2)+(6*6)+(5*9)+(4*3)+(3*9)+(2*4)+(1*4)=187
187 % 10 = 7
So 1426939-44-7 is a valid CAS Registry Number.
1426939-44-7Relevant articles and documents
Oxidation kinetics of simvastatin using cetyltrimethylammonium dichromate
Sahoo, Prangya Rani,Patel, Sabita,Mishra
, p. 236 - 242 (2013)
This article reports an attempt on the studies on resistance of oxidative stress by the prodrug, simvastatin (SV). Cetyltrimethylammonium dichromate has been used as a lipid compatible oxidant to study the oxidation kinetics of SV in organic media. The reaction undergoes via an ionic mechanism without any side product. The reaction is found to be acid catalyzed and sensitive to solvent polarity. The increase in the rate constant due to an increase in hydrophobicity (apolarity) of the solvent indicates the existence of a less polar transition state. Furthermore, the decrease in the rate constant due to an increase in [CTAB] suggests partitioning of the substrates and the oxidants into two different domains with different polar characteristics akin to a reversed micellar aggregates. Considering the above results and the thermodynamic parameters, a reaction mechanism has been proposed, wherein a complex formed at the interface of the two domains due to the reactant and the oxidant in a fast process decomposes to the products in a slow process in the nonpolar bulk.
