1427171-69-4 Usage
Description
(3R,3aS)-3-(hydroxymethyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3a,4-dihydro-1H,3H-benzo[b]oxazolo[3,4-d][1,4]oxazin-1-one is a complex organic compound featuring a heterocyclic structure with a dioxaborolane moiety and an oxazoquinoline ring system. The presence of a hydroxymethyl group suggests its potential as a building block for synthesizing other organic compounds. This unique structure and potential reactivity may offer applications in medicinal chemistry, pharmaceutical research, and material science, warranting further studies and research to explore its full potential across various fields.
Uses
Used in Medicinal Chemistry:
(3R,3aS)-3-(hydroxymethyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3a,4-dihydro-1H,3H-benzo[b]oxazolo[3,4-d][1,4]oxazin-1-one is used as a synthetic intermediate for the development of novel pharmaceutical compounds due to its complex heterocyclic structure and potential reactivity, which can be exploited in the creation of new drugs with specific therapeutic properties.
Used in Pharmaceutical Research:
In pharmaceutical research, this compound serves as a key building block for the synthesis of complex organic molecules with potential medicinal applications. Its unique structure allows for the exploration of new chemical spaces and the discovery of innovative therapeutic agents.
Used in Material Science:
(3R,3aS)-3-(hydroxymethyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3a,4-dihydro-1H,3H-benzo[b]oxazolo[3,4-d][1,4]oxazin-1-one is utilized in material science for the development of new materials with specific properties. Its heterocyclic structure and functional groups may contribute to the creation of advanced materials for various applications, such as sensors, catalysts, or novel polymers.
Check Digit Verification of cas no
The CAS Registry Mumber 1427171-69-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,7,1,7 and 1 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1427171-69:
(9*1)+(8*4)+(7*2)+(6*7)+(5*1)+(4*7)+(3*1)+(2*6)+(1*9)=154
154 % 10 = 4
So 1427171-69-4 is a valid CAS Registry Number.
1427171-69-4Relevant articles and documents
Efficient and stereoselective one-pot synthesis of benzo[b] oxazolo[3,4- d] [1,4]oxazin-1-ones
Cheng, Shihao,Huang, Haihong,Lu, Haijia,Zhang, Dongfeng,Zhao, Hongyi,Zhao, Wenting
, p. 24037 - 24044 (2020)
An efficient and mild one-pot convergent synthesis protocol has been developed for benzo[b]oxazolo[3,4-d][1,4]oxazin-1-one derivatives through the Mitsunobu reaction and sequential cyclization. Various tricyclic fused benzoxazinyl-oxazolidinones (20 examp
Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl- oxazolidinones leading to a promising antibacterial agent
Guo, Bin,Fan, Houxing,Xin, Qisheng,Chu, Wenjing,Wang, Hui,Huang, Yanqin,Chen, Xiaoyan,Yang, Yushe
, p. 2642 - 2650 (2013/05/09)
The solubility-driven structural modification of (pyridin-3-yl) benzoxazinyl-oxazolidinones is described, which resulted in the development of a new series of benzoxazinyl-oxazolidinone analogues with high antibacterial activity against Gram-positive pathogens, including that against linezolid-resistant strains and low hERG inhibition. With regard to structure-activity relationship (SAR) trends among the various substituents on the pyridyl ring, relatively small and nonbasic substituents were preferable to sterically demanding or basic substituents. Oxazolidinone ring substitution on the pyridyl ring generated analogues with antibacterial activity superior to imidazolidinone ring. Solubility was enhanced by the incorporation of polar groups, especially when compounds were converted to their prodrugs. Among the prodrugs, compound 85 exhibited excellent solubility and a good pharmacokinetic profile. In a MRSA systemic infection model, compound 85 displayed an ED 50 = 5.00 mg/kg, a potency that is 2-fold better than that of linezolid.
