1427177-23-8 Usage
Description
(RS)-2-(4-(3-chloro-2-hydroxyphenyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide is a complex organic molecule characterized by a piperazine core, a chlorinated hydroxyphenyl group, and an acetamide functional group attached to a substituted aminophenyl moiety. The presence of two chiral centers, denoted as (RS)-, indicates the existence of both enantiomers in the compound. Its structural resemblance to known bioactive compounds suggests potential pharmacological activities, and the chlorinated hydroxyphenyl group may allow for interactions with biological targets, making it a promising candidate for drug development and medicinal chemistry research.
Uses
Used in Pharmaceutical Industry:
(RS)-2-(4-(3-chloro-2-hydroxyphenyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide is used as a potential drug candidate for various therapeutic applications due to its structural similarities to known bioactive compounds and the presence of a chlorinated hydroxyphenyl group, which may facilitate interactions with biological targets.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (RS)-2-(4-(3-chloro-2-hydroxyphenyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide serves as a valuable compound for studying its pharmacological activities and potential interactions with biological targets. This research could lead to the development of new drugs or the improvement of existing ones.
Used in Drug Design and Optimization:
(RS)-2-(4-(3-chloro-2-hydroxyphenyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide can be utilized in drug design and optimization processes, where its unique structural features and potential pharmacological activities can be further explored and enhanced to create more effective and targeted therapeutic agents.
Used in Chemical Synthesis:
(RS)-2-(4-(3-chloro-2-hydroxyphenyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide (RS)-2-(4-(3-chloro-2-hydroxyphenyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide may also find applications in chemical synthesis, where it can be used as a building block or a starting material for the synthesis of other complex molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 1427177-23-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,7,1,7 and 7 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1427177-23:
(9*1)+(8*4)+(7*2)+(6*7)+(5*1)+(4*7)+(3*7)+(2*2)+(1*3)=158
158 % 10 = 8
So 1427177-23-8 is a valid CAS Registry Number.
1427177-23-8Relevant articles and documents
Compounds for treating anginapectoris, preparation method and application
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Paragraph 0039; 0040; 0047; 0048, (2017/09/01)
The invention relates to the field of medicinal chemistry, and particularly relates to compounds I, II and III corporation ranolazine derivatives or pharmaceutically acceptable salt thereof, a preparation method of the compounds, a medicinal composition containing the compounds and medical application of the compounds. Pharmacodynamic experiments prove that the compounds disclosed by the invention have an effect of treating anginapectoris. (the compounds are shown in the specification).
"All water chemistry" for a concise total synthesis of the novel class anti-anginal drug (RS), (R), and (S)-ranolazine
Kommi, Damodara N.,Kumar, Dinesh,Chakraborti, Asit K.
, p. 756 - 767 (2013/03/29)
A novel strategy of 'all water chemistry' is reported for a concise total synthesis of the novel class anti-anginal drug ranolazine in its racemic (RS) and enantiopure [(R) and (S)] forms. The reactions at the crucial stages of the synthesis are promoted by water and led to the development of new water-assisted chemistries for (i) catalyst/base-free N-acylation of amine with acyl anhydride, (ii) base-free N-acylation of amine with acyl chloride, (iii) catalyst/base-free one-pot tandem N-alkylation and N-Boc deprotection, and (iv) base-free selective mono-alkylation of diamine (e.g., piperazine). The distinct advantages in performing the reactions in water have been demonstrated by performing the respective reactions in organic solvents that led to inferior results and the beneficial effect of water is attributed to the synergistic electrophile and nucleophile dual activation role of water. The new 'all water' strategy offers two green processes for the total synthesis of ranolazine in two and three steps with 77 and 69% overall yields, respectively, and which are devoid of the formation of the impurities that are generally associated with the preparation of ranolazine following the reported processes.
