142721-22-0Relevant articles and documents
Analogues of the potent nonpolyglutamatable antifolate N(α)-(4-amino-4- deoxypteroyl)-N(δ)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: Synthesis and in vitro antitumor activity
Rosowsky, Andre,Wright, Joel E.,Vaidya, Chitra M.,Forsch, Ronald A.,Bader, Henry
, p. 1620 - 1634 (2007/10/03)
Seven N(α)-(4-amino-4-deoxypteroyl)-N(δ)-hemiphthaloyl-L-ornithine (2, PT523) analogues were synthesized by modifications of the literature synthesis of the corresponding AMT (1) analogues and were tested as inhibitors of tumor cell growth. In growth assa
Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin
Degraw,Christie,Tagawa,Kisliuk,Gaumont,Schmid,Sirotnak
, p. 1056 - 1061 (2007/10/02)
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