142761-12-4 Usage
Description
S-(+)-O-DESMETHYLVENLAFAXINE, a metabolite of Venlafaxine, is a selective serotonin noradrenaline reuptake inhibitor (SNRI). It is a white to off-white solid and is primarily known for its role in the treatment of depression.
Uses
Used in Pharmaceutical Industry:
S-(+)-O-DESMETHYLVENLAFAXINE is used as an antidepressant for the treatment of depression. It works by inhibiting the reuptake of serotonin and noradrenaline, thereby increasing their levels in the brain and improving mood.
Used in High-Dose Venlafaxine Treatment:
S-(+)-O-DESMETHYLVENLAFAXINE is also used as a component in high-dose venlafaxine treatment for depressed patients with a genetic CYP2D6 deficiency. This deficiency can lead to reduced effectiveness of venlafaxine, and the use of S-(+)-O-DESMETHYLVENLAFAXINE can help overcome this limitation and provide better treatment outcomes for these patients.
Check Digit Verification of cas no
The CAS Registry Mumber 142761-12-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,7,6 and 1 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 142761-12:
(8*1)+(7*4)+(6*2)+(5*7)+(4*6)+(3*1)+(2*1)+(1*2)=114
114 % 10 = 4
So 142761-12-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3/t15-/m1/s1
142761-12-4Relevant articles and documents
N-OXIDES OF VENLAFAXINE AND O-DESMETHYLVENLAFAXINE AS PRODRUGS
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Page/Page column 7, (2009/01/24)
Embodiments of the invention relate to a compound of formula (1), or a tautomer, stereoisomer, hydrate, or solvate thereof, wherein R1 is H or CH3. Other embodiments of the invention relate to a pharmaceutical composition containing these compound, to methods for preparing these compounds, and to methods for preparing compositions containing these compounds. Yet other embodiments of the invention relate to the uses of these compounds and compositions containing it, such as for the manufacture of medicaments and pharmaceutical compositions for treating a condition chosen from depression, major depressive disorder, generalized anxiety disorder, obsessive compulsive disorder, social anxiety disorder, panic disorder, general depressive disorders, diabetic neuropathy, migraine and hot flashes.
