1427803-90-4

Basic information

• Product Name: 1-(2,5-difluorophenyl)-3-(4-tolyl)prop-2-yn-1-one
• Synonyms: 1-(2,5-difluorophenyl)-3-(4-tolyl)prop-2-yn-1-one
• CAS NO: 1427803-90-4
• Molecular Weight: 256.252
• Mol File: 1427803-90-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,5-difluorophenyl)-3-(4-tolyl)prop-2-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,5-difluorophenyl)-3-(4-tolyl)prop-2-yn-1-one(1427803-90-4)
• EPA Substance Registry System: 1-(2,5-difluorophenyl)-3-(4-tolyl)prop-2-yn-1-one(1427803-90-4)

Safety Data

• Hazardous Substances Data: 1427803-90-4(Hazardous Substances Data)

Upstream product

• 35730-09-7 2,5-difluorobenzoyl chloride 
• 766-97-2 4-n-methylphenylacetylene 

Downstream Products

• 1427804-06-5 6-fluoro-1-(2-phenylethyl)-2-(4-tolyl)quinolin-4(1H)-one 
• 1427804-07-6 6-fluoro-1-(3-phenylpropyl)-2-(4-tolyl)quinolin-4(1H)-one 
• 1427804-05-4 6-fluoro-1-hexyl-2-(4-tolyl)quinolin-4(1H)-one 

Relevant articles and documents

Efficient [5+1] synthesis of 4-quinolones by domino amination and conjugate addition reactions of 1-(2-fluorophenyl)prop-2-yn-1-ones with amines

A catalyst-free synthetic approach is described for the synthesis of 4-quinolone derivatives through a tandem amination/conjugated Michael addition sequence of 1-(2-fluorophenyl)prop-2-yn-1-one derivatives. The [5+1]-cyclization proceeds efficiently at a high temperature under an inert atmosphere with lithium carbonate as a base, and it provides a practical route to a diverse range of 4-quinolones. The mechanism was studied in details and several of the intermediates were isolated. Georg Thieme Verlag Stuttgart New York.