142797-34-0

Basic information

• Product Name: SILYBIN (A and B)(P)
• Synonyms: SILYBIN (A and B)(P);NSC 227190;Silibinin B;(2R,3R)-3,5,7-Trihydroxy-2-[(2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin-6-yl]-4-chromanone;(2S,3S)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-[(2R,3R)-3,5,7-trihydroxy-4-oxobenzopyran-2-yl]benzodioxin
• CAS NO: 142797-34-0
• Molecular Formula: C₂₅H₂₂O₁₀
• Molecular Weight: 482.43618
• Mol File: 142797-34-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 158-160℃ (methanol water )
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: SILYBIN (A and B)(P)(CAS DataBase Reference)
• NIST Chemistry Reference: SILYBIN (A and B)(P)(142797-34-0)
• EPA Substance Registry System: SILYBIN (A and B)(P)(142797-34-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 142797-34-0(Hazardous Substances Data)

Usage

Description

SILYBIN (A and B)(P) is a natural occurring flavolignan derived from the seeds of the milk thistle plant (Silybum marianum). It consists of two isomers, SILYBIN A and SILYBIN B, which possess various biological activities, including anti-inflammatory and anti-fibrogenic properties. The compound is characterized by its unique structure, which allows it to interact with various cellular targets and exhibit therapeutic effects.

Uses

Used in Pharmaceutical Industry:
SILYBIN (A and B)(P) is used as a therapeutic agent for its anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells. This makes it a promising candidate for the treatment of liver diseases, such as hepatitis and cirrhosis, where inflammation and fibrosis play significant roles in disease progression.
Additionally, due to its antioxidant and radical scavenging properties, SILYBIN (A and B)(P) can be used as a supplement in the nutraceutical industry to support liver health and promote overall well-being.
Used in Cosmetic Industry:
SILYBIN (A and B)(P) can be utilized as an active ingredient in cosmetic products, particularly those targeting skin health and regeneration. Its anti-inflammatory properties can help reduce skin irritation and promote healing, making it suitable for use in skincare products for various skin conditions, such as acne, eczema, and dermatitis.
Used in Research and Development:
SILYBIN (A and B)(P) serves as a valuable compound for scientific research, particularly in the fields of pharmacology, toxicology, and biochemistry. Its unique structure and biological activities make it an interesting subject for studying the mechanisms of action, potential drug interactions, and the development of novel therapeutic strategies for various diseases.

Upstream product

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Relevant articles and documents

Total synthesis of (±)-silybin, an antihepatotoxic flavonolignan

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