1428258-40-5

Basic information

• Product Name: 2,3-dihydro-2-benzyl-1,5-benzothiazepin-4(5H)-one
• Synonyms: 2,3-dihydro-2-benzyl-1,5-benzothiazepin-4(5H)-one
• CAS NO: 1428258-40-5
• Molecular Weight: 269.367
• Mol File: 1428258-40-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,3-dihydro-2-benzyl-1,5-benzothiazepin-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-2-benzyl-1,5-benzothiazepin-4(5H)-one(1428258-40-5)
• EPA Substance Registry System: 2,3-dihydro-2-benzyl-1,5-benzothiazepin-4(5H)-one(1428258-40-5)

Safety Data

• Hazardous Substances Data: 1428258-40-5(Hazardous Substances Data)

Upstream product

• 2243-52-9 3-benzylacrylic acid 
• 137-07-5 2-amino-benzenethiol 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 1428258-36-9 C₂₃H₂₀N₂O₃S 

Relevant articles and documents

Design, synthesis and biological evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β (GSK-3β)

Glycogen synthase kinase-3β (GSK-3β) plays a key role in type II diabetes and Alzheimer's diseases, to which non-ATP competitive inhibitors represent an effectively therapeutical approach due to their good specificity. Herein, a series of small molecules benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of GSK-3β have been designed and synthesized. The in vitro evaluation performed by luminescent assay showed most BTZ derivatives have inhibitory effects in micromolar scale. Among them compounds 6l, 6t and 6v have the IC50 values of 25.0 μM, 27.8 μM and 23.0 μM, respectively. Moreover 6v is devoid of any inhibitory activity in the assays to other thirteen protein kinases. Besides, SAR is analyzed and a hypothetical enzymatic binding mode is proposed by molecular docking study, which would be useful for new candidates design.