1428580-30-6Relevant articles and documents
Synthesis of functionalized lipids, and their use for a tunable hydrophobization of nucleosides and nucleic acids
Korneev, Sergei,Rosemeyer, Helmut
, p. 201 - 216 (2013)
Two series of functionalized single and double side-chained lipid molecules (Schemes 1 and 2) were prepared. The compounds carry either terminal COOH, OH, or halogen substituents. Moreover, the double side-chained lipid 18 carries an internal alkyne functionality. The latter compound was used to hydrophobize thymidine at N(3) by base-catalyzed alkylation. Additionally, fully protected thymidine, 32, was N(3)-alkylated with the double side-chained alcohol 9 applying Mitsunobu reaction conditions. Copyright
Reactive, lipophilic nucleoside building blocks for the synthesis of hydrophobic nucleic acids
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Paragraph 0162, (2014/05/06)
The present invention relates to a method for the isolation and/or identification of known or unknown sequences of nucleic acids (target sequences) optionally marked with reporter groups by base specific hybridation with, essentially, complementary sequences (in the following referred to as sample oligonucleotides, sample sequences or sample nucleic acids), which belong to a library of sequences. Further, the invention relates to nucleolipids used in the method of the invention and a process for the preparation of said nucleolipids.