1428857-81-1

Basic information

• Product Name: C₂₃H₁₈N₂O₃
• CAS NO: 1428857-81-1
• Molecular Weight: 370.408
• Mol File: 1428857-81-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₁₈N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₁₈N₂O₃(1428857-81-1)
• EPA Substance Registry System: C₂₃H₁₈N₂O₃(1428857-81-1)

Safety Data

• Hazardous Substances Data: 1428857-81-1(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 25739-23-5 4-(phenylethynyl)benzoic acid 

Relevant articles and documents

Exploring the UDP pocket of LpxC through amino acid analogs

Lipopolysaccharide (LPS) biosynthesis is an attractive antibacterial target as it is both conserved and essential for the survival of key pathogenic bacteria. Lipid A is the hydrophobic anchor for LPS and a key structural component of the outer membrane of Gram-negative bacteria. Lipid A biosynthesis is performed in part by a unique zinc dependent metalloamidase, LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase), which catalyzes the first non-reversible step in lipid A biosynthesis. The UDP portion of the LpxC substrate-binding pocket has been relatively unexplored. We have designed and evaluated a series of hydroxamate based inhibitors which explore the SAR of substitutions directed into the UDP pocket with a range of substituted α-amino acid based linkers. We also provide the first wild type structure of Pseudomonas aeruginosa LpxC which was utilized in the design of many of these analogs.