1428976-23-1

Basic information

• Product Name: ethyl 2-(1-benzylpiperidin-3-ylidene)-2-fluoroacetate
• Synonyms: ethyl 2-(1-benzylpiperidin-3-ylidene)-2-fluoroacetate
• CAS NO: 1428976-23-1
• Molecular Weight: 277.339
• Mol File: 1428976-23-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-(1-benzylpiperidin-3-ylidene)-2-fluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(1-benzylpiperidin-3-ylidene)-2-fluoroacetate(1428976-23-1)
• EPA Substance Registry System: ethyl 2-(1-benzylpiperidin-3-ylidene)-2-fluoroacetate(1428976-23-1)

Safety Data

• Hazardous Substances Data: 1428976-23-1(Hazardous Substances Data)

Upstream product

• 1428976-14-0 (2-ethoxy-1-fluoro-2-oxoethyl)trimethylphosphonium bromide 
• 50606-58-1 N-benzyl-3-piperidinone hydrochloride 
• 40114-49-6 1-benzyl-3-piperidone 
• 125950-57-4 (2-ethoxy-1-fluoro-2-oxoethyl)triphenylphosphonium bromide 

Downstream Products

• 1428976-68-4 C₁₆H₂₀FNO₂*C₇H₈O₃S 

Relevant articles and documents

Origin of the E/Z Selectivity in the Synthesis of Tetrasubstituted Olefins by Wittig Reaction of α-Fluorophosphonium Ylides: An Explanation for the Low Stereoselectivity Observed in Reactions of α-Alkoxy Aldehydes

A series of tetrasubstituted fluoroalkenes were synthesized in good yield and high E/Z selectivity (up to 96/4) by Wittig reaction between α-heterosubstituted ketones and α-fluorophosphonium ylides. A detailed study of factors that control stereoselectivity in these reactions shows that stereoselectivity is the result of stabilizing CH···F and N···C=O interactions in the addition TS leading to the E isomer. This analysis provides a rationale for the observed decrease in selectivity for reactions of stabilized ylides with α-alkoxy aldehydes.