1429293-49-1

Basic information

• Product Name: N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-ethyl-4-methoxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide
• Synonyms: N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-ethyl-4-methoxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide
• CAS NO: 1429293-49-1
• Molecular Weight: 385.29
• Mol File: 1429293-49-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-ethyl-4-methoxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-ethyl-4-methoxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide(1429293-49-1)
• EPA Substance Registry System: N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-ethyl-4-methoxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide(1429293-49-1)

Safety Data

• Hazardous Substances Data: 1429293-49-1(Hazardous Substances Data)

Upstream product

• 5336-43-6 ethyl 1-ethyl-4,5-dioxopyrrolidine-3-carboxylate 
• 1429293-25-3 1-ethyl-4-methoxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid 
• 1429204-43-2 4-(3,4-dichlorophenyl)butan-2-amine hydrochloride 
• 1146294-57-6 ethyl 1-ethyl-4-methoxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate 
• 93467-64-2 4-(3,4-dichlorophenyl)butan-2-amine 
• 1429293-32-2 3-(3,4-dichlorophenyl)-N-methoxy-N-methylpropanamide 
• 42160-40-7 4-(3,4-dichlorophenyl)butan-2-one 
• 25173-68-6 3(3,4-dichlorophenyl)propanoic acid 

Downstream Products

• 1429291-98-4 N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide 

Relevant articles and documents

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor

Screening of a small set of nonselective lipase inhibitors against endothelial lipase (EL) identified a potent and reversible inhibitor, N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide (5; EL IC50 = 6

PYRROLINONE CARBOXAMIDE COMPOUNDS USEFUL AS ENDOTHELIAL LIPASE INHIBITORS

The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments. The disclosure also provi