14294-11-2

Basic information

• Product Name: 2-PYRIDYLTHIOUREA
• Synonyms: AKOS BBS-00007311;1-(2-PYRIDYL)-2-THIOUREA;1-PYRIDIN-2-YLTHIOUREA;2-PYRIDYLTHIOUREA;N-PYRIDIN-2-YLTHIOUREA;N-(2-Pyridyl)thiourea, 98%;Thiourea,N-2-pyridinyl-;N-2-Pyridinyl-Thiourea
• CAS NO: 14294-11-2
• Molecular Formula: C₆H₇N₃S
• Molecular Weight: 153.2
• EINECS: -0
• Product Categories: Pyridines
• Mol File: 14294-11-2.mol
• Article Data: 30

Chemical Properties

• Melting Point: 148-150°C
• Boiling Point: 298.7 °C at 760 mmHg
• Flash Point: 134.4 °C
• Appearance: /
• Density: 1.382 g/cm³
• Refractive Index: 1.651
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 12.00±0.70(Predicted)
• BRN: 117849
• CAS DataBase Reference: 2-PYRIDYLTHIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDYLTHIOUREA(14294-11-2)
• EPA Substance Registry System: 2-PYRIDYLTHIOUREA(14294-11-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 14294-11-2(Hazardous Substances Data)

Usage

Description

2-PYRIDYLTHIOUREA is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its ability to form disubstituted thiazoles and 2-amino-5-(thioaryl)thiazoles, which exhibit potent biological activities.

Uses

Used in Pharmaceutical Industry:
2-PYRIDYLTHIOUREA is used as an intermediate for the synthesis of disubstituted thiazoles, which have potential applications as antibacterial and anti-inflammatory agents. This is due to their ability to condense with phenacyl bromide, thioureas, and thiosemicarbazones, resulting in compounds with significant therapeutic properties.
Additionally, 2-PYRIDYLTHIOUREA is used as a precursor in the synthesis of 2-amino-5-(thioaryl)thiazoles. These compounds have been identified as potent and selective inhibitors of Itk, a protein tyrosine kinase involved in various cellular processes. Inhibiting Itk has been shown to have potential therapeutic benefits in treating autoimmune diseases and certain cancers, making 2-PYRIDYLTHIOUREA an important compound in the development of novel therapeutic agents.

InChI:InChI=1/C6H7N3OS/c7-6(10)9-11-5-3-1-2-4-8-5/h1-4H,(H3,7,9,10)

Upstream product

• 52648-45-0 2-pyridylisothiocyanate 
• 504-29-0 2-aminopyridine 
• 1147550-11-5 ammonium thiocyanate 
• 886-60-2 1-(2'-pyridyl)-3-phenylthiourea 
• 103-72-0 phenyl isothiocyanate 
• 13037-46-2 pyridin-2-yl-dithiocarbamic acid methyl ester 
• 150-76-5 4-methoxy-phenol 
• 4921-86-2 N-benzoyl-N'-(2-pyridyl)thiourea 

Downstream Products

• 54670-80-3 N-(thiazol-2-yl)pyridin-2-amine 
• 3833-85-0 4-fluoro-2-(2-pyridin-2-ylamino-thiazol-4-yl)-phenol 
• 846-69-5 4-fluoro-2-(5-methyl-2-pyridin-2-ylamino-thiazol-4-yl)-phenol 
• 79571-55-4 4-(5-Nitro-2-furyl)-2-(2-pyridylamino)thiazole 
• 79571-72-5 4-(3,4-Dihydroxyphenyl)-2-(2-pyridylamino)thiazole hydrochloride 
• 79571-76-9 4-(2,3,4-Trihydroxyphenyl)-2-(2-pyridylamino)thiazole hydrochloride 
• 339231-86-6 N-(4-(2-(pyridin-2-ylamino)thiazol-4-yl)phenyl)acetamide 
• 79571-60-1 4-(2,4,5-Trichlorophenyl)-2-(2-pyridylamino)thiazole 
• 13575-41-2 [1,3]thiazolo[4,5-b]pyridin-2-amine 
• 439579-07-4 3-[2-(pyridin-2-ylamino)-thiazol-5-ylsulfanyl]-benzoic acid 
• 639859-08-8 4-fluoro-3-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzoic acid 
• 639859-07-7 N-Cyclopropyl-4-fluoro-3-{[2-(pyridin-2-ylamino)-thiazol-5-ylmethyl]-amino}-benzamide 

Related news

Preparation of ruthenium (III) ion-imprinted beads based on 2-PYRIDYLTHIOUREA (cas 14294-11-2) modified chitosan07/18/2019

Ru(III) ion-imprinted bio-adsorbent based on 2-pyridylthiourea modified chitosan (Ru-PTCS) had been manufactured, investigated and employed for selective extraction of Ru(III) ions from aqueous medium containing interfering metal ions that maybe coexist and compete with Ru(III) ions. Elemental a...detailed

Relevant articles and documents

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SO2F2-Mediated N-Alkylation of Imino-Thiazolidinones

The N-alkylation of ambident and weakly nucleophilic imino-thiazolidinones has been developed via substitution with alkyl fluorosulfonates. These reactive electrophiles are obtained through the transformation of nontoxic, economic, and commercially availa

Design, synthesis and biological evaluation of novel HSP70 inhibitors: N, N′-disubstituted thiourea derivatives

As novel heat shock protein 70 (HSP70) inhibitors, N, N′-disubstituted thiourea derivatives were designed and synthesized based on the X-ray structure of the ATPase domain (nucleotide binding domain, NBD). An ATPase activity inhibition assay revealed that these compounds effectively inhibited HSP70 ATPase activity. The results revealed that the compounds 370/371/374/379/380//392/394/397/404/405 and 407 can inhibit the HSP70 ATPase turnover with high percentages of inhibition: 50.42, 38.46, 50.45, 44.12, 47.13, 50.50, 40.95, 65.36, 46.23, 35.78, and 58.37 in 200 μM, respectively. Significant synergies with lapatinib were observed for compound 379 and compound 405 in the BT474 breast cancer cell line. A structure-function analysis revealed that most of the thiourea derivatives exhibited cooperative action with lapatinib in the BT474 cancer cell line and the BT/LapR1.0 lapatinib-resistant cell line. HSP70 inhibitors may be developed as synergetic drugs in drug-resistant cancer therapy.