1429431-02-6

Basic information

• Product Name: C₁₈H₂₂O₂
• CAS NO: 1429431-02-6
• Molecular Weight: 270.371
• Mol File: 1429431-02-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₂O₂(1429431-02-6)
• EPA Substance Registry System: C₁₈H₂₂O₂(1429431-02-6)

Safety Data

• Hazardous Substances Data: 1429431-02-6(Hazardous Substances Data)

Upstream product

• 6581-57-3 cis- and trans-2,6-Dimethoxytetrahydropyran 
• 111-30-8 Glutaraldehyde 
• 16640-69-0 4-phenyl-1-(triphenylphosphoranylidene)butan-2-one 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 

Relevant articles and documents

Synthesis and Biological Evaluation of Tricyclic Guanidine Analogues of Batzelladine K for Antimalarial, Antileishmanial, Antibacterial, Antifungal, and Anti-HIV Activities

Fifty analogues of batzelladine K were synthesized and evaluated for in vitro antimalarial (Plasmodium falciparum), antileishmanial (Leishmania donovani), antimicrobial (panel of bacteria and fungi), antiviral (HIV-1) activities. Analogues 14h and 20l exhibited potential antimalarial activity against chloroquine-sensitive D6 strain with IC50 1.25 and 0.88μm and chloroquine-resistant W2 strain with IC50 1.64 and 1.07μm, respectively. Analogues 12c and 14c having nonyl substitution showed the most potent antileishmanial activity with IC50 2.39 and 2.78μm and IC90 11.27 and 12.76μm, respectively. Three analogues 12c, 14c, and 14i were the most active against various pathogenic bacteria and fungi with IC503.02μm and MIC/MBC/MFC 6μm. Analogue 20l having pentyl and methyl substituents on tricycle showed promising activities against all pathogens. However, none was found active against HIV-1. Our study demonstrated that the tricyclic guanidine compounds provide new structural class for broad spectrum activity. Fifty analogues of tricyclic guanidine derivative of batzelladine K were synthesized and tested for antimalarial, antileishmanial, antimicrobial, antifungal and anti-HIV activities. We have identified several active analogues.