14300-15-3

Basic information

• Product Name: 2'-(2-Oxopropyl)acetanilide
• Synonyms: 2'-(2-Oxopropyl)acetanilide;N-[2-(2-Oxopropyl)phenyl]acetamide
• CAS NO: 14300-15-3
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol File: 14300-15-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 376.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.131±0.06 g/cm3(Predicted)
• PKA: 14.89±0.70(Predicted)
• CAS DataBase Reference: 2'-(2-Oxopropyl)acetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-(2-Oxopropyl)acetanilide(14300-15-3)
• EPA Substance Registry System: 2'-(2-Oxopropyl)acetanilide(14300-15-3)

Safety Data

• Hazardous Substances Data: 14300-15-3(Hazardous Substances Data)

Upstream product

• 615-43-0 2-iodophenylamine 
• 123-54-6 acetylacetone 

Relevant articles and documents

Intramolecular cooperative C-C bond cleavage reaction of 1,3-dicarbonyl compounds with 2-iodoanilines to give o-(N-Acylamino)aryl ketones and multisubstituted indoles

A copper-catalyzed C-C bond cleavage reaction of 1,3-dicarbonyl compounds with 2-iodoanilines was developed. In this process, the ortho effect played an important role in the reactivity and a new reaction pathway that involved a (2-aminophenyl)-bis-(1,3-dicarbonyl) copper species was clearly observed by a time-course HRMS analysis of the reaction mixture. Unlike the previous reports, both the nucleophilic and electrophilic parts of the 1,3-dicarbonyl compound were coupled with 2-iodoaniline by C-C bond cleavage to form o-(N-acylamino)aryl ketones, which could be efficiently converted into multisubstituted indoles.