1430061-09-8

Basic information

• Product Name: (2S)-(2-chlorophenyl){[(1S)-1-(4-methoxyphenyl)ethyl]amino}acetonitrile hydrochloride
• Synonyms: (2S)-(2-chlorophenyl){[(1S)-1-(4-methoxyphenyl)ethyl]amino}acetonitrile hydrochloride
• CAS NO: 1430061-09-8
• Molecular Weight: 337.249
• Mol File: 1430061-09-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-(2-chlorophenyl){[(1S)-1-(4-methoxyphenyl)ethyl]amino}acetonitrile hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-(2-chlorophenyl){[(1S)-1-(4-methoxyphenyl)ethyl]amino}acetonitrile hydrochloride(1430061-09-8)
• EPA Substance Registry System: (2S)-(2-chlorophenyl){[(1S)-1-(4-methoxyphenyl)ethyl]amino}acetonitrile hydrochloride(1430061-09-8)

Safety Data

• Hazardous Substances Data: 1430061-09-8(Hazardous Substances Data)

Upstream product

• 574744-39-1 (1S)-[1-(4-methoxyphenyl)ethyl]amine hydrochloride 
• 773837-37-9 sodium cyanide 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 113665-84-2 (S)-(+)-clopidogrel 
• 225918-58-1 (2S)-2-(2-chlorophenyl)glycine hydrochloride 
• 141109-14-0 methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate 
• 120202-66-6 (S)-(+)-clopidogrel bisulfate 

Relevant articles and documents

An asymmetric synthesis of clopidogrel hydrogen sulfate

An asymmetric synthesis of (S)-(+)-clopidogrel hydrogen sulfate has been developed through application of a Strecker reaction with [(1S)-1-(4- methoxyphenyl)ethyl]amine hydrochloride as a chiral auxiliary. Addition of 2-chlorobenzaldehyde to a solution of sodium cyanide and [(1S)-1-(4- methoxyphenyl)ethyl]amine hydrochloride gave diastereoisomerically pure (2S)-(2-chlorophenyl){[(1S)-1-(4-methoxyphenyl)ethyl]amino}acetonitrile hydro chloride. Cleavage of the chiral auxiliary and concomitant hydrolysis of the nitrile group then gave enantiomerically pure (2S)-2-(2-chlorophenyl)glycine hydrochloride, a key intermediate for (S)-(+)-clopidogrel. Georg Thieme Verlag Stuttgart. New York.