1430111-73-1Relevant articles and documents
Syntheses and anti-allergic activity of 2-((bis(trimethylsilyl)methylthio/ methylsulfonyl)methyl)-5-aryl-1,3,4-oxadiazoles
Guda, Dinneswara Reddy,Park, Sae-Jin,Lee, Min-Woo,Kim, Tack-Joong,Lee, Myong Euy
, p. 84 - 88 (2013/05/22)
A new class of sila-substituted 1,3,4-oxadiazoles was synthesized by a convenient synthetic method. Both silathio/silasulfonyl acetic acids were efficiently condensed with benzohydrazides in the presence of phosphorus oxychloride to give sila-substituted 1,3,4-oxadiazoles in high yields. The compounds displayed variable extent of anti-allergic activity on IgE/Ag-stimulated RBL-2H3 cells at 50 and 100 μM concentrations. Compounds having sulfonyl moiety with bis(trimethylsilyl)-1,3,4-oxadiazoles (5a-c), exhibited better anti-allergic activities than those of compounds having sulphur moiety with bis(trimethylsilyl)-1,3,4-oxadiazoles (4a-c).