1430111-75-3

Basic information

• Product Name: 2-((bis(trimethylsilyl)-methylsulfonyl)methyl)-5-phenyl-1,3,4-oxadiazole
• Synonyms: 2-((bis(trimethylsilyl)-methylsulfonyl)methyl)-5-phenyl-1,3,4-oxadiazole
• CAS NO: 1430111-75-3
• Molecular Weight: 382.631
• Mol File: 1430111-75-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-((bis(trimethylsilyl)-methylsulfonyl)methyl)-5-phenyl-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((bis(trimethylsilyl)-methylsulfonyl)methyl)-5-phenyl-1,3,4-oxadiazole(1430111-75-3)
• EPA Substance Registry System: 2-((bis(trimethylsilyl)-methylsulfonyl)methyl)-5-phenyl-1,3,4-oxadiazole(1430111-75-3)

Safety Data

• Hazardous Substances Data: 1430111-75-3(Hazardous Substances Data)

Upstream product

• 5926-35-2 chlorobis(trimethylsilyl)methane 
• 1430111-71-9 2-(bis(trimethylsilyl)methylsulfonyl)acetic acid 
• 613-94-5 benzoic acid hydrazide 
• 1430111-70-8 2-(bis(trimethylsilyl)methylthio)acetic acid 

Relevant articles and documents

Syntheses and anti-allergic activity of 2-((bis(trimethylsilyl)methylthio/ methylsulfonyl)methyl)-5-aryl-1,3,4-oxadiazoles

A new class of sila-substituted 1,3,4-oxadiazoles was synthesized by a convenient synthetic method. Both silathio/silasulfonyl acetic acids were efficiently condensed with benzohydrazides in the presence of phosphorus oxychloride to give sila-substituted 1,3,4-oxadiazoles in high yields. The compounds displayed variable extent of anti-allergic activity on IgE/Ag-stimulated RBL-2H3 cells at 50 and 100 μM concentrations. Compounds having sulfonyl moiety with bis(trimethylsilyl)-1,3,4-oxadiazoles (5a-c), exhibited better anti-allergic activities than those of compounds having sulphur moiety with bis(trimethylsilyl)-1,3,4-oxadiazoles (4a-c).