1430414-12-2Relevant articles and documents
Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents
Kamal, Ahmed,Swapna,Shetti, Rajesh V.C.R.N.C.,Shaik, Anver Basha,Narasimha Rao,Gupta, Soma
, p. 661 - 669 (2013/05/09)
A number of linezolid-like oxazolidino-sulfonamides (7a-y and 8a-b) were designed and synthesized with a view to develop antimicrobial agents with improved properties. Most of the synthesized compounds showed good to moderate activity against a panel of standard Gram-positive and Gram-negative bacteria and fungal strains. The compounds 7i and 7v exhibited significant activity, with a MIC value of 2.0-6.0 μg/mL against a panel of Gram-positive and Gram-negative bacteria. These compounds also showed activity against Candida albicans, with a MIC value of 4.0 μg/mL. A correlation of the antimicrobial activity with calculated lipophilicity values (C log P) is also presented.