1430418-89-5

Basic information

• Product Name: 4-(2-(4-acetylphenyl)pyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol
• Synonyms: 4-(2-(4-acetylphenyl)pyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol
• CAS NO: 1430418-89-5
• Molecular Weight: 383.45
• Mol File: 1430418-89-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-(4-acetylphenyl)pyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-(4-acetylphenyl)pyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol(1430418-89-5)
• EPA Substance Registry System: 4-(2-(4-acetylphenyl)pyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol(1430418-89-5)

Safety Data

• Hazardous Substances Data: 1430418-89-5(Hazardous Substances Data)

Upstream product

• 1430418-83-9 2-(2-(4-acetylphenyl)pyridin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone 
• 1217181-38-8 2-(2-chloropyridin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone 
• 149104-90-5 4-acetylphenylboronic acid 
• 3678-62-4 2-chloro-4-picoline 
• 108593-44-8 methyl 3-methoxy-5-methylbenzoate 

Relevant articles and documents

Design, synthesis and in-vitro screening of new 1h-pyrazole and 1,2-isoxazole derivatives as potential inhibitors for ROS and mapk14 Kinases

A new series of 4-(2-(substituted)pyridin-4-yl)-3-(3-methoxy-5- methylphenyl)-1H-pyrazoles (4a-f) and their 1,2-isoxazole analogues (5a-f) has been rationally designed, synthesized and screened against both ROS and MAPK14 kinases. Compounds 4b, 4c and 4e showed moderate inhibitions against both ROS and MAPK14 kinases. Compound 4e has showed the strongest inhibitions with IC50 values of 1.25 andμM and 3.00 andμM against ROS and MAPK14 kinases, respectively. A brief structure-activity relationship study and a molecular modeling study were made revealing a group of essential structural features for good kinase inhibitory activity within this new class of kinase inhibitors.