14313-44-1

Basic information

• Product Name: Phenol, 2-(5-chloro-1H-benzimidazol-2-yl)-
• CAS NO: 14313-44-1
• Molecular Formula: C13H9ClN2O
• Molecular Weight: 244.68
• Mol File: 14313-44-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Phenol, 2-(5-chloro-1H-benzimidazol-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-(5-chloro-1H-benzimidazol-2-yl)-(14313-44-1)
• EPA Substance Registry System: Phenol, 2-(5-chloro-1H-benzimidazol-2-yl)-(14313-44-1)

Safety Data

• Hazardous Substances Data: 14313-44-1(Hazardous Substances Data)

Upstream product

• 65-45-2 salicylamide 
• 90-02-8 salicylaldehyde 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 77773-92-3 2,3-Dihydro-2,2-diethyl-4H-1,3-benzoxazin-4-one 
• 74405-11-1 4-Chloro-2,2-diethyl-2H-benzo[e][1,3]oxazine 

Downstream Products

• 1155842-35-5 5-chloro-2-[2-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-benzimidazole 
• 1155842-33-3 5-chloro-2-[2-(2-morpholin-4-ylethoxy)phenyl]-1H-benzimidazole 
• 1155842-34-4 5-chloro-2-[2-(2-piperidin-1-ylethoxy)phenyl]-1H-benzimidazole 
• 1155842-36-6 2-[2-(5-chloro-1H-benzimidazol-2-yl)phenoxy]-N,N-diethylethanamine 
• 104620-05-5 1-[3-(5-Chloro-1H-benzoimidazol-2-yl)-4-hydroxy-phenyl]-nonan-1-one 
• 104620-04-4 1-[3-(5-Chloro-1H-benzoimidazol-2-yl)-4-hydroxy-phenyl]-octan-1-one 
• 104620-03-3 1-[3-(5-Chloro-1H-benzoimidazol-2-yl)-4-hydroxy-phenyl]-heptan-1-one 

Relevant articles and documents

Synthesis and characterization of Ni(II) complexes bearing of 2-(1H–benzimidazol-2-yl)-phenol derivatives as highly active catalysts for ethylene oligomerization

Novel Ni(II) complexes of 2-(1H–benzimidazol-2-yl)-phenol derivatives (HLx: x = 1–5; C1–C5) have been synthesized and characterized. In the mononuclear complexes, the ligands were coordinated as bidentate, via one imine nitrogen and the phenola

Method for catalytically synthesizing benzimidazole compound in water phase under microwave radiation

The invention discloses a method for catalytically synthesizing a benzimidazole compound in a water phase under microwave radiation. The method comprises the following steps: adding a catalytic amount of metal chloride, proline lithium and a substituted 2-halogenated aniline substrate, ammonia water, a benzaldehyde derivative, inorganic alkali and water into a reaction container; putting the reaction container into a microwave reaction instrument to react at certain temperature and under certain power; after certain time, decompressing and concentrating; purifying a product through a column chromatography to obtain the benzimidazole compound, wherein the metal chloride in the step is iron chloride, cobalt chloride, nickel chloride or copper chloride, the inorganic alkali in the step is sodium hydroxide, cesium carbonate, sodium carbonate, potassium hydroxide or potassium phosphate, and reaction temperature of the microwave reaction instrument is 20 DEG C to 200 DEG C. The method for preparing the benzimidazole compound, provided by the invention, is environmental-friendly, is simple and convenient to operate, is safe and cheap and is efficient. Compared with the prior art, the method has the advantages of moderate reaction conditions, simplicity in operation, high yield, safety, low cost and environmental friendliness.

Synthesis and biological activity evaluation of 1H-benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays

Benzimidazoles are important compounds because of their antibacterial, antifungal, antimicrobial, antiprotozoal and antihelmintic activities. Some benzimidazole derivatives also interfere with the reactions of DNA topoisomerases, enzymes functioning at al