1431555-06-4

Basic information

• Product Name: N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide
• Synonyms: N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide
• CAS NO: 1431555-06-4
• Molecular Weight: 696.248
• Mol File: 1431555-06-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide(1431555-06-4)
• EPA Substance Registry System: N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide(1431555-06-4)

Safety Data

• Hazardous Substances Data: 1431555-06-4(Hazardous Substances Data)

Upstream product

• 1312592-31-6 C₂₄H₂₈N₂O₇ 
• 72836-33-0 2-amino-5-((4-chlorobenzyl)mercapto)-1,3,4-thiadiazole 
• 114099-32-0 N-deacetyl-10-methylamino-10-demethoxycolchicine 
• 2826-80-4 N-methyl colchiceinamide 

Relevant articles and documents

Synthesis and cytotoxic evaluation of new colchicine derivatives bearing 1,3,4-thiadiazole moieties

In search of novel anticancer agents, a series of N-methyl colchiceinamide derivatives (7a-7i) containing 1,3,4-thiadiazole moieties were synthesized, and their structures were confirmed by spectral analysis. Cytotoxicity of these compounds was evaluated by MTT assay in vitro against four human tumor cell lines, i.e. A2780, A549, BEL7402, and MCF-7. The results indicated that most of the derivatives showed significant anticancer activities, particularly, compounds 7h and 7i showed more potent cytotoxic activities of all screened cancer cells than colchicine.