1431561-98-6

Basic information

• Product Name: 4′-ethoxy-1-tosyl-1H,1′H-2,2′-bipyrrole
• Synonyms: 4′-ethoxy-1-tosyl-1H,1′H-2,2′-bipyrrole
• CAS NO: 1431561-98-6
• Molecular Weight: 330.408
• Mol File: 1431561-98-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4′-ethoxy-1-tosyl-1H,1′H-2,2′-bipyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 4′-ethoxy-1-tosyl-1H,1′H-2,2′-bipyrrole(1431561-98-6)
• EPA Substance Registry System: 4′-ethoxy-1-tosyl-1H,1′H-2,2′-bipyrrole(1431561-98-6)

Safety Data

• Hazardous Substances Data: 1431561-98-6(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 1431561-92-0 C₂₀H₂₃N₃O₅S 
• 102619-05-6 1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde 
• 98-59-9 p-toluenesulfonyl chloride 
• 1003-29-8 2-pyrrole aldehyde 

Relevant articles and documents

Substituted 2,2′-bipyrroles and pyrrolylfurans via intermediate isoxazolylpyrroles

We describe a new synthesis of the 3-chloro-(4′-methoxy)-2,2′- pyrrolylfuran segment (3) of (+)-roseophilin. The route exploits a isoxazoylpyrrole intermediate, wherein the isoxazole ring serves as a β-diketone equivalent and a directing group for palladium catalyzed chlorination of the attached pyrrole. Subsequent reduction of the N-O bond and acid promoted cyclization afford roseophilin segment 3b in five steps and 19% overall yield. This strategy was extended to the synthesis of 3-chloro-(4′-alkoxy)-2,2′-pyrrolylfurans (16a-c) and 4-alkoxy-2,2′-bipyrroles (20a-c), which are building blocks to synthesize bioactive prodiginine natural products and their congeners.