1431726-17-8Relevant articles and documents
Catalytic asymmetric synthesis of pyrroloindolines via a rhodium(II)-catalyzed annulation of indoles
Spangler, Jillian E.,Davies, Huw M. L.
supporting information, p. 6802 - 6805 (2013/06/05)
Herein we report the synthesis of pyrroloindolines via a catalytic enantioselective formal [3+2] cycloaddition of C(3)-substituted indoles. This methodology utilizes 4-aryl-1-sulfonyl-1,2,3-triazoles as carbenoid precursors and the rhodium(II)-tetracarboxylate catalyst Rh2(S-PTAD) 4. A variety of aryl-substituted pyrroloindolines were prepared in good yields and with high levels of enantioinduction.