143361-87-9

Basic information

• Product Name: 3-BENZOTHIAZOL-2-YL-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHEN-2-YLAMINE
• Synonyms: 3-(Benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-aMine
• CAS NO: 143361-87-9
• Molecular Formula: C₁₅H₁₄N₂S₂
• Molecular Weight: 286.42
• Mol File: 143361-87-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 526.9 °C at 760 mmHg
• Flash Point: 272.5 °C
• Appearance: /
• Density: 1.363 g/cm³
• Vapor Pressure: 3.42E-11mmHg at 25°C
• Refractive Index: 1.738
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-BENZOTHIAZOL-2-YL-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHEN-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BENZOTHIAZOL-2-YL-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHEN-2-YLAMINE(143361-87-9)
• EPA Substance Registry System: 3-BENZOTHIAZOL-2-YL-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHEN-2-YLAMINE(143361-87-9)

Safety Data

• Hazardous Substances Data: 143361-87-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 29, p. 1027, 1992 DOI: 10.1002/jhet.5570290463

InChI:InChI=1/C15H14N2S2/c16-14-13(9-5-1-3-7-11(9)18-14)15-17-10-6-2-4-8-12(10)19-15/h2,4,6,8H,1,3,5,7,16H2

Upstream product

• 137-07-5 2-amino-benzenethiol 
• 56278-50-3 2-cyanomethylbenzothiazole 
• 108-94-1 cyclohexanone 
• 4506-71-2 ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 

Downstream Products

• 1452809-50-5 3-(benzo[d]thiazol-2-yl)-N-(4-fluorobenzylidene)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-amine 
• 1452809-51-6 3-(benzo[d]thiazol-2-yl)-N-(4-chlorobenzylidene)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-amine 
• 1452809-54-9 3-(benzo[d]thiazol-2-yl)-N-(2-chlorobenzylidene)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-amine 
• 476281-63-7 2-((3-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylimino)methyl)phenol 
• 476281-59-1 3-(benzo[d]thiazol-2-yl)-N-benzylidene-4,5,6,7-tetrahydrobenzo[b]thiophen-2-amine 
• 1452809-55-0 3-(benzo[d]thiazol-2-yl)-N-(2-nitrobenzylidene)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-amine 
• 389065-44-5 3-(benzo[d]thiazol-2-yl)-N-(4-nitrobenzylidene)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-amine 
• 1452809-56-1 3-(benzo[d]thiazol-2-yl)-N-(4-(trifluoromethyl)benzylidene)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-amine 
• 1452809-57-2 3-(benzo[d]thiazol-2-yl)-N-(3,4,5-trimethoxybenzylidene)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-amine 
• 1161343-20-9 N-(3-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4'-chlorobiphenyl-4-sulfonamide 

Relevant articles and documents

Novel cycloalkylthiophene-imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation

A series of novel cycloalkylthiophene-imine derivatives containing benzothiazole unit were designed, synthesized and evaluated for their anti-viral activities. The bio-evaluation results indicated that some of the target compounds (such as 5g, 5i, 5u) exhibited good to moderate antiviral effect on CVB5, ADV7 and EV71 viruses, however, these compounds did not have inhibition activity against H1N1 virus. Especially, the compounds 4c and 4d also exhibited high antiviral activities, which provide a new and efficient approach to evolve novel multi-functional antiviral agents by rational integration of active pharmacophores.

Synthesis of 3-Hetaryl-4,5,6,7-tetrahydrobenzothiophenes

A novel efficient synthesis of 3-hetaryl-4,5,6,7-tetrahydrobenzothiophenes was achieved by the cyclocondensation of ethyl 2-amino-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate with selected o-substituted aromatic amines or with alifatic, aromatic a