143426-48-6

Basic information

• Product Name: Ethyl 4-(1,2,4-Triazol-1-yl)benzoate
• Synonyms: Ethyl 4-(1,2,4-Triazol-1-yl)benzoate;Ethyl 4-(1H-1,2,4-triazol-1-yl);Ethyl 4-(1H-1,2,4-triazol-1-yl)benzoate
• CAS NO: 143426-48-6
• Molecular Formula: C₁₁H₁₁N₃O₂
• Molecular Weight: 217.22
• Product Categories: Acids and Derivatives;Heterocycles
• Mol File: 143426-48-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 378.5°C at 760 mmHg
• Flash Point: 182.7°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 6.25E-06mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Ethyl 4-(1,2,4-Triazol-1-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-(1,2,4-Triazol-1-yl)benzoate(143426-48-6)
• EPA Substance Registry System: Ethyl 4-(1,2,4-Triazol-1-yl)benzoate(143426-48-6)

Safety Data

• Hazardous Substances Data: 143426-48-6(Hazardous Substances Data)

Usage

General Description

Ethyl 4-(1,2,4-triazol-1-yl)benzoate is a chemical compound with the molecular formula C14H12N2O2. It is commonly used in the synthesis of pharmaceutical drugs and agrochemicals. This chemical is a triazole derivative, which is a class of compounds known for their diverse biological activities. Ethyl 4-(1,2,4-triazol-1-yl)benzoate has potential applications in the treatment of various diseases, including cancer, fungal infections, and bacterial infections. Its unique structure and reactivity make it a valuable building block in the development of new therapeutic agents and other biologically active compounds. Furthermore, it is also used as an intermediate in the production of other chemicals and materials.

InChI:InChI=1/C11H11N3O2/c1-2-16-11(15)9-3-5-10(6-4-9)14-8-12-7-13-14/h3-8H,2H2,1H3

Upstream product

• 288-88-0 1,2,4-Triazole 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 162848-16-0 4-(1H-1,2,4-triazol-1-yl)-benzoic acid 
• 27996-86-7 4-(1H-1,2,4-triazol-1-yl)benzaldehyde 
• 139311-96-9 3-(4-[1,2,4]Triazol-1-yl-phenyl)-propionic acid hydrazide 
• 143426-73-7 3-(4-[1,2,4]Triazol-1-yl-phenyl)-propionic acid ethyl ester 
• 143426-65-7 (4-[1,2,4]Triazol-1-yl-phenyl)-acetic acid ethyl ester 
• 139311-95-8 (4-[1,2,4]Triazol-1-yl-phenyl)-acetic acid hydrazide 
• 143426-70-4 (E)-3-(4-[1,2,4]Triazol-1-yl-phenyl)-acrylic acid ethyl ester 
• 143426-64-6 (4-[1,2,4]Triazol-1-yl-phenyl)-acetic acid 
• 143426-56-6 4-(1H-1,2,4-triazol-1-yl)phenylacetonitrile 
• 143426-53-3 1-(4-(chloromethyl)phenyl)-1H-1,2,4-triazole 
• 58419-68-4 4-[1,2,4]Triazol-1-yl-benzoic acid hydrazide 
• 143426-50-0 [4-(1H-1,2,4-triazol-1-yl)phenyl]methanol 

Relevant articles and documents

Sulfonamide derivatives, their production and use

The present invention provides compounds which specifically inhibit FXa, which are effective when orally administered and which are useful as a safe medicine for the prevention or treatment of diseases caused by thrombus or infarction. Compounds of this invention are piperazinones of the formula: wherein R1is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; the ring A is an optionally substituted divalent nitrogen-containing heterocyclic group, in addition to being substituted by the group of the formula: and the group of the formula: Y is an optionally substituted divalent hydrocarbon group or an optionally substituted divalent heterocyclic group; X is a direct bond or an optionally substituted alkylene chain; Z is (1) an amino group substituted with an optionally substituted hydrocarbon group, (2) an optionally substituted imino group or (3) an optionally substituted nitrogen-containing heterocyclic group; provided that when X is a direct bond and Z is an optionally substituted 6-membered nitrogen-containing aromatic heterocyclic group, Y is an optionally substituted divalent hydrocarbon group or an optionally substituted divalent unsaturated heterocyclic group; or a salt thereof.

Aromatic hydrazides as specific inhibitors of bovine serum amine oxidase

New hydrazides were synthesized in search for specific inhibitors of bovine serum amine oxidase: a series of benzoic and phenylacetic acid hydrazides containing the 1H-imidazol-1-yl or the 1H-imidazol-1-ylmethyl group as (o,m,p)-substituent in the phenyl ring; an analogous series of p-substituted phenylhydrazides with 5 or 6-membered heterocyclic ring as substituent, and a series of similar phenylpropionic hydrazides. The longer and more flexible phenylacetic hydrazides, and to a somewhat lesser extent the phenylpropionic ones, were better specific inhibitors of bovine serum amine oxidase than the benzoic hydrazides, which were also bound by the enzyme with high affinity, but at a slow rate. Derivatives with p- and m-substituents were more reactive than the o-substituted ones. The chemical nature of the substituent was less important than its position in the phenyl ring and the presence of methylene spacers. These data point to the presence of a hydrophobic site at short distance from the protein carbonyl cofactor, so that simultaneous interaction of the 2 ends of the inhibitor molecule can occur at the 2 sites. The presence of the hydrophobic site was confirmed by the capability of some molecule deprived of the hydrazidic group to act as mild inhibitors. All hydrazides were less reactive by 2-3 orders of magnitude towards pig kidney diamine oxidase and FAD-dependent monoamine oxidase from rat brain mitochondria, while the other compounds showed similar inhibition power against all proteins. The specificity for the bovine enzyme seems therefore to be related to the concerted action of the 2 moieties of the inhibitor molecule.