143427-03-6

Basic information

• Product Name: 1-Heptanone, 2-chloro-1-phenyl-
• CAS NO: 143427-03-6
• Molecular Formula: C13H17ClO
• Molecular Weight: 224.73
• Mol File: 143427-03-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Heptanone, 2-chloro-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Heptanone, 2-chloro-1-phenyl-(143427-03-6)
• EPA Substance Registry System: 1-Heptanone, 2-chloro-1-phenyl-(143427-03-6)

Safety Data

• Hazardous Substances Data: 143427-03-6(Hazardous Substances Data)

Usage

Type of compound

Ketone

Structure

Seven-carbon chain with a ketone group and a chloro-phenyl group attached at the second carbon

Usage

Solvent, intermediate in the production of other chemicals, fragrance industry, flavoring agent in food products, potential use in pharmaceutical applications (e.g. treatment of neurological disorders)

Safety precautions

Can cause skin and eye irritation, harmful if ingested or inhaled, should be handled with caution.

Upstream product

• 19233-44-4 [(2-chloro-2-propenyl)-oxo]benzene 
• 543-63-5 n-butylmercuric chloride 

Relevant articles and documents

Reductive alkylation of electronegatively-substituted alkenes by alkylmercury halides

Photolysis of alkylmercury halides in the presence of electronegatively-substituted 1-alkenes yields adduct radicals [RCH2CH(EWG).] that in some cases react with RHgX to form RCH2CH(HgX)(EWG), e.g., EWG = (EtO)2PO or PhSO2. When the EWG is carbonyl or cyano, the resonance stabilized adduct radicals fail to react with the alkyl mercury halide. In these cases photolysis with RHgCl/KI in Me2SO leads to the adduct mercurial via reaction of the adduct radicals with RHgI2-. The reactions of tertiary-enolyl adduct radicals are inefficient with RHgX/KI, and disproportionation of the adduct radicals is the major reaction pathway. For secondary- or tertiary-adduct radicals the reductive alkylation products are formed in excellent yield by reaction with RHgCl and silyl hydrides in Me2SO solution in a process postulated to involve RHgH as an intermediate. The relative reactivities of a number of α,β-unsaturated systems toward t-Bu. have been measured by competitive techniques. The results demonstrate a high reactivity of s-cis enones relative to the s-trans conformers.