14347-24-1

Basic information

• Product Name: N-[5-(2-BROMO-ACETYL)-2-HYDROXY-PHENYL]-METHANESULFONAMIDE
• Synonyms: N-[5-(2-BROMO-ACETYL)-2-HYDROXY-PHENYL]-METHANESULFONAMIDE;N-[5-(2-Bromo-acetyl)-2-hydroxy-phenyl]-;Methanesulfonamide, N-[5-(2-bromoacetyl)-2-hydroxyphenyl]-
• CAS NO: 14347-24-1
• Molecular Formula: C₉H₁₀BrNO₄S
• Molecular Weight: 308.15
• Mol File: 14347-24-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 465.2°Cat760mmHg
• Flash Point: 235.1°C
• Appearance: /
• Density: 1.78g/cm³
• Vapor Pressure: 2.82E-09mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: N-[5-(2-BROMO-ACETYL)-2-HYDROXY-PHENYL]-METHANESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[5-(2-BROMO-ACETYL)-2-HYDROXY-PHENYL]-METHANESULFONAMIDE(14347-24-1)
• EPA Substance Registry System: N-[5-(2-BROMO-ACETYL)-2-HYDROXY-PHENYL]-METHANESULFONAMIDE(14347-24-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 14347-24-1(Hazardous Substances Data)

Usage

Description

N-[5-(2-BROMO-ACETYL)-2-HYDROXY-PHENYL]-METHANESULFONAMIDE is a chemical compound with a complex structure that features a bromoacetyl group attached to a hydroxyphenyl moiety, which is then connected to a methanesulfonamide group. N-[5-(2-BROMO-ACETYL)-2-HYDROXY-PHENYL]-METHANESULFONAMIDE is characterized by its reactivity and potential applications in various fields, particularly in the pharmaceutical and biochemical industries.

Uses

Used in Biochemical Research:
N-[5-(2-BROMO-ACETYL)-2-HYDROXY-PHENYL]-METHANESULFONAMIDE is used as a reactant in the characterization of monoacylglycerol acyltransferase 2 (MGAT2) inhibitors. This application is based on its ability to act as a probe in binding assays, which helps researchers understand the interactions between the compound and the target enzyme, MGAT2. This knowledge can be crucial for the development of new drugs and therapies that target this enzyme, which is involved in lipid metabolism and has been linked to various metabolic disorders and diseases.

InChI:InChI=1/C9H10BrNO4S/c1-16(14,15)11-7-4-6(9(13)5-10)2-3-8(7)12/h2-4,11-12H,5H2,1H3

Upstream product

• 14347-18-3 1-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethanone 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 662111-56-0 N-[2-hydroxy-5-((1R)-1-hydroxy-2-{[(1S)-2-hydroxy-1-phenylethyl]amino}ethyl)phenyl]methanesulfonamide 

Relevant articles and documents

Catecholamine surrogates useful as β3 agonists

Compounds of the formula STR1 or pharmaceutically acceptable salts thereof wherein: A is a bond, --(CH 2) n -- or --CH(B)--, where n is an integer of 1 to 3 and B is --CN, --CON(R 9)R 9'' or --CO 2 R 7 ;R 1 is lower alkyl, aryl or arylalkyl;R 2 is hydrogen, hydroxy, alkoxy, --CH 2 OH, cyano, --C(O)OR 7, --CO 2 H, --CONH 2, tetrazole, --CH 2 NH 2 or halogen; STR2 R 3 is hydrogen, alkyl, heterocycle or R 4 is hydrogen, alkyl or B;R 5, R 5'', R 8, R 8'' or R 8"" are independently hydrogen, alkoxy, lower alkyl, halogen, --OH, --CN, --(CH 2) n NR 6 COR 7, --CON(R 6)R 6'', --CON(R 6)OR 6'', --CO 2 R 6, --SR 7, --SOR 7, --SO 2 R 7, --N(R 6)SO 2 R 1, --N(R 6)R 6'', --NR 6 COR 7, --OCH 2 CON(R 6)R 6'', --OCH 2 CO 2 R 7 or aryl; orR 5 and R 5'' or R 8 and R 8'' may together with the carbon atoms to which they are attached form an aryl or heterocycle;R 6 and R 6'' are independently hydrogen or lower alkyl; andR 7 is lower alkyl;R 9 is hydrogen, lower alkyl, alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl; or R 9 and R 9'' may together with the nitrogen atom to which they are attached form a heterocycle; with the proviso that when A is a bond or --(CH 2) n and R 3 is hydrogen or unsubstituted alkyl, then R 4 is B or substituted alkyl. These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity and gastrointestinal diseases.