1434816-93-9

Basic information

• Product Name: 2-chloro-4-fluoro-1-tritylsulfanylbenzene
• Synonyms: 2-chloro-4-fluoro-1-tritylsulfanylbenzene
• CAS NO: 1434816-93-9
• Molecular Weight: 404.935
• Mol File: 1434816-93-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-fluoro-1-tritylsulfanylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-fluoro-1-tritylsulfanylbenzene(1434816-93-9)
• EPA Substance Registry System: 2-chloro-4-fluoro-1-tritylsulfanylbenzene(1434816-93-9)

Safety Data

• Hazardous Substances Data: 1434816-93-9(Hazardous Substances Data)

Upstream product

• 76-84-6 triphenylmethyl alcohol 
• 175277-99-3 2-chloro-4-fluorobenzenethiol 

Downstream Products

• 1434816-87-1 2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenethiol 
• 1434816-99-5 2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)-1-tritylsulfanyl benzene 
• 1252634-14-2 (2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)amide 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES

The present invention relates in part to a process for the preparation of a proline derivative of formula I wherein, R1 is C1-7-alkyl or wherein R4 is selected from the group consisting of C1-7-alkyl, halogen-C1-7-alkyl and phenyl optionally substituted by halogen; R2 is halogen or halogen-C1-7-alkyl; and R3 is selected from the group consisting of hydrogen, halogen, halogen-C1-7-alkyl, C1-7-alkoxy, halogen-C1-7-alkoxy and a 5- or 6-membered heterocyclic ring containing one or two nitrogen atoms, said ring being optionally substituted by C1-7-alkyl or halogen. The proline derivatives of the formula I are preferential inhibitors of the cysteine protease Cathepsin S and are therefore useful to treat metabolic diseases like diabetes, atherosclerosis, abdominal aortic aneurysm, peripheral arterial disease and diabetic nephropathy.