143527-63-3

Basic information

• Product Name: C₅₂H₅₈Cl₆FNO₁₈
• Synonyms: C₅₂H₅₈Cl₆FNO₁₈
• CAS NO: 143527-63-3
• Molecular Weight: 1216.74
• Mol File: 143527-63-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₅₂H₅₈Cl₆FNO₁₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₂H₅₈Cl₆FNO₁₈(143527-63-3)
• EPA Substance Registry System: C₅₂H₅₈Cl₆FNO₁₈(143527-63-3)

Safety Data

• Hazardous Substances Data: 143527-63-3(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 136265-10-6 ethyl 4-fluorocinnamate 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 32981-86-5 10-deacetylbaccatin III 
• 1300036-08-1 C₁₂H₁₃FO₂ 
• 1300036-09-2 isopropyl (2R,3S)-3-acetylamino-2-hydroxy-3-(4-fluorophenyl)propionate 
• 154306-83-9 (3R,4S)-3-hydroxy-4-(4-fluorophenyl)-1-[(S)-1-phenyl]ethyl-2-azetidinone 
• 154306-86-2 (4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester 
• 154306-84-0 methyl (2R,3S)-2-hydroxy-3-[(S)-1-phenyl]ethylamino-3-(4-fluorophenyl)propionate 
• 154306-85-1 methyl (2R,3S)-3-tert-butoxy-carbonylamino-2-hydroxy-3-(4-fluorophenyl)propionate 
• 157240-38-5 methyl (2R,3S)-3-amino-2-hydroxy-3-(4-fluoro-phenyl)propionate 
• 95603-44-4 7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III 
• 143527-64-4 (4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 

Downstream Products

• 143527-61-1 3'-dephenyl-3'-(4-fluorophenyl)docetaxel 
• 143527-60-0 C₄₉H₅₄Cl₆FNO₁₈ 
• 1300036-11-6 N-de-tert-butoxycarbonyl-N-[2-(1-fluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel 
• 1300036-12-7 N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel 
• 1300036-13-8 N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel 
• 1300036-07-0 N-de-tert-butoxycarbonyl-N-[2-(1-fluoro-2-methyl)propyloxycarbonyl]-3-dephenyl-3'-(4-fluorophenyl)docetaxel 
• 1300036-14-9 N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)propyloxycarbonyl]-3-dephenyl-3'-(4-fluorophenyl)docetaxel 
• 1300036-15-0 N-de-tert-butoxycarbonyl-N-[2-(1,1,1-trifluoro-2-methyl)propyloxycarbonyl]-3-dephenyl-3'-(4-fluorophenyl)docetaxel 

Relevant articles and documents

Synthesis, cytotoxicity, metabolic stability and pharmacokinetic evaluation of fluorinated docetaxel analogs

Three novel fluorinated docetaxel analogs, along with six previous reported, were evaluated for their cytotoxicity against five tumor cell lines. The results indicated that these analogs maintained similar/more potent activity than docetaxel against these tumor cell lines. They were also evaluated for their metabolic stability and pharmacokinetics, which demonstrated that these analogs showed better profiles of metabolic stability and pharmacokinetics than that of docetaxel.