143653-60-5 Usage
Description
2'-O-ACETYL-5'-O-BENZOYL-3'-DEOXY-5-METHYLURIDINE is a chemical compound that belongs to the class of deoxyribonucleosides and their derivatives. It is characterized by its unique structure, which includes an acetyl group at the 2' position, a benzoyl group at the 5' position, and a methyl group at the 5 position. 2'-O-ACETYL-5'-O-BENZOYL-3'-DEOXY-5-METHYLURIDINE has potential applications in various fields due to its specific properties and interactions with biological systems.
Uses
Used in Pharmaceutical Industry:
2'-O-ACETYL-5'-O-BENZOYL-3'-DEOXY-5-METHYLURIDINE is used as a therapeutic agent for the treatment of certain diseases. Its application in this industry is due to its potential as an anti-amoebic agent, which can help in the treatment of infections caused by amoebic parasites.
Used in Research and Development:
In the field of biological research, 2'-O-ACETYL-5'-O-BENZOYL-3'-DEOXY-5-METHYLURIDINE serves as a valuable compound for studying the structure and function of deoxyribonucleosides and their derivatives. Its unique properties make it an interesting subject for understanding the interactions between these molecules and biological systems, which can lead to the development of new therapeutic strategies and drug candidates.
Used in Drug Design and Synthesis:
The compound's specific structural features make it a useful building block in the design and synthesis of new drugs targeting various diseases. Its potential as an anti-amoebic agent can be further explored and optimized to develop more effective treatments for amoebic infections.
Check Digit Verification of cas no
The CAS Registry Mumber 143653-60-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,6,5 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 143653-60:
(8*1)+(7*4)+(6*3)+(5*6)+(4*5)+(3*3)+(2*6)+(1*0)=125
125 % 10 = 5
So 143653-60-5 is a valid CAS Registry Number.
143653-60-5Relevant articles and documents
Stereocontrolled Syntheses of Deoxyribonucleosides via Photoinduced Electron-Transfer Deoxygenation of Benzoyl-Protected Ribo- and Arabinonucleosides
Wang, Zhiwei,Prudhomme, Daniel R.,Buck, Jason R.,Park, Minnie,Rizzo, Carmelo J.
, p. 5969 - 5985 (2007/10/03)
The stereocontrolled, de novo syntheses of β-2′-deoxy-, α-2′-deoxy-, β-3′-deoxy-, and β-2′,3′-dideoxyribonucleosides are described. Strategically protected ribose, arabinose, and xylose glycosylation precursors were synthesized bearing C2-esters capable of directing Vorbrueggen glycosylation. The key step is the regioselective deoxygenation of the desired hydroxyl group as either the benzoyl- or 3-(trifluoromethyl)benzoyl derivative. This deoxygenation is accomplished via a photoinduced electron-transfer (PET) mechanism using carbazole derivatives as the photosensitizer. The syntheses of the desired deoxynucleoside generally proceed in three steps from a common, readily available precursor.
3'-Deoxy-2'-phosphoramidites of adenosine and 5-methyluridine used for the solid phase synthesis of unnatural 3'-deoxy-2'-5''-oligonucleotides
Rizzo,Dougherty,Breslow
, p. 4129 - 4132 (2007/10/02)
Protected phosphoramidites of 3'-deoxyadenosine and 3'-deoxy-5-methyluridine have been synthesized, and used in solid phase synthesis of 3'-deoxyoligonucleotides with the unusual 2'-5'' linkage.
