143665-56-9

Basic information

• Product Name: Benzenebutanamide, 4-amino-N-[(3,4-dimethoxyphenyl)methyl]-N-methyl-
• CAS NO: 143665-56-9
• Molecular Formula: C20H26N2O3
• Molecular Weight: 342.438
• Mol File: 143665-56-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenebutanamide, 4-amino-N-[(3,4-dimethoxyphenyl)methyl]-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenebutanamide, 4-amino-N-[(3,4-dimethoxyphenyl)methyl]-N-methyl-(143665-56-9)
• EPA Substance Registry System: Benzenebutanamide, 4-amino-N-[(3,4-dimethoxyphenyl)methyl]-N-methyl-(143665-56-9)

Safety Data

• Hazardous Substances Data: 143665-56-9(Hazardous Substances Data)

Upstream product

• 63-64-9 N-methylveratrylamine 
• 5600-62-4 4-(4-nitrophenyl)butanoic acid 
• 5600-63-5 4-(4-nitrophenyl)butanoyl chloride 
• 143665-55-8 N-(3,4-Dimethoxy-benzyl)-N-methyl-4-(4-nitro-phenyl)-butyramide 

Downstream Products

• 143665-57-0 4-{4-[(3,4-Dimethoxy-benzyl)-methyl-amino]-butyl}-phenylamine 

Relevant articles and documents

Synthesis and Activity against Multidrug Resistance in Chinese Hamster Ovary Cells of New Acridone-4-carboxamides

A number of tricyclic carboxamides have been synthesized and tested to evaluate their ability to reverse multidrug resistance in the CHRC/5 cell line.Among them the acridone derivatives were the most potent.A key feature is the presence of a dimethoxybenzyl or phenethylamine cationic site, separated from the tricyclic lipophilic part by a carbamoylphenyl chain.Optimization led to compounds 2 orders of magnitude more active than the prototype inhibitors verapamil and amiodarone.On the basis of in vitro and in vivo activities, 9,10-dihydro-5-methoxy-9-oxo-N-phenyl>-4-acridinecarboxamide (84) has been selected for further development.