14377-63-0

Basic information

• Product Name: 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)
• Synonyms: 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI);1-phenyl-2-(piperidin-1-yl)ethane-1,2-dione;1-phenyl-2-(piperidin-1-yl)ethane-1,2-dione(WXC04924)
• CAS NO: 14377-63-0
• Molecular Formula: C₁₃H₁₅NO₂
• Molecular Weight: 217.2637
• Product Categories: Methylphenidate
• Mol File: 14377-63-0.mol
• Article Data: 95

Chemical Properties

• Melting Point: 107-108 °C
• Boiling Point: 343.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.154±0.06 g/cm3(Predicted)
• PKA: -1.36±0.20(Predicted)
• CAS DataBase Reference: 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)(14377-63-0)
• EPA Substance Registry System: 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)(14377-63-0)

Safety Data

• Hazardous Substances Data: 14377-63-0(Hazardous Substances Data)

Usage

General Description

1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- is a chemical compound used in the synthesis of pharmaceuticals and organic compounds. It is a piperidine derivative that has been studied for its potential analgesic and anesthetic properties. Piperidine, 1-(oxophenylacetyl)- (9CI), also known as phenacetyl piperidine, is an organic compound with potential anticonvulsant and anti-inflammatory properties. It is used in the synthesis of various pharmaceuticals and research chemicals. Both chemicals have potential applications in the pharmaceutical industry and in the development of new therapeutic agents.

Upstream product

• 110-89-4 piperidine 
• 1074-12-0 phenylglyoxal hydrate 
• 591-50-4 iodobenzene 
• 67-66-3 chloroform 
• 779-52-2 1-phenyl-2-piperidin-1-yl-ethanone 
• 98-86-2 acetophenone 
• 4636-16-2 iodoacetophenone 
• 201230-82-2 carbon monoxide 
• 13665-04-8 2,2-dibromoacetophenone 
• 3626-62-8 2-phenyl-1-(1-piperidinyl)ethanone 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 666749-77-5 methyl 2-(2,2-diphenyl-3,3-dichloroaziridin-1-yl)-2-phenylacetate 
• 17506-94-4 1-<(piperidin-1-ylcarbonyl)carbonyl>piperidine 
• 591-51-5 phenyllithium 

Relevant articles and documents

Mesoporous poly-melamine-formaldehyde stabilized palladium nanoparticle (Pd@mPMF) catalyzed mono and double carbonylation of aryl halides with amines

A new mesoporous poly-melamine-formaldehyde material supported Pd nano catalyst (mPMF-Pd0) has been synthesized and characterized by thermogravimetric analysis (TGA), powder X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDS), high-resolution transmission electron microscopy (HRTEM), UV-vis diffuse reflection spectroscopy (DRS), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) and a N2 adsorption study. The mPMF-Pd0 material showed very good catalytic activity in the field of mono and double amino carbonylation of aryl bromides/iodides. Moreover, the catalyst is easily recoverable and can be reused six times without appreciable loss of catalytic activity in the above reactions. So, the highly dispersed and strongly bound palladium(0) sites in the mPMF-Pd0 could be responsible for the observed high activities. Due to strong binding with the functional groups of the polymer, no evidence of leached Pd from the catalyst during the course of reaction occurred, suggesting true heterogeneity in the catalytic process. This journal is

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Diversification of α-ketoamides: Via transamidation reactions with alkyl and benzyl amines at room temperature

A wide range of N-tosyl α-ketoamides underwent transamidation with various alkyl amines in the absence of a catalyst, base, or additive. On the other hand, transamidation in N-Boc α-ketoamides was achieved in the presence of Cs2CO3. The reactions proceede

Ligand-free Zn-catalyzed double carbonylation of aryl iodides with secondary amines: A simple and efficient approach to access α-ketoamides

Herein, we report a Zinc catalyzed double carbonylation of aryl iodides with secondary amines under CO pressure for the synthesis of α-ketoamides in good to excellent yields. This methodology provides a simple and economic approach to derivatize useful α-