143773-34-6

Basic information

• Product Name: 22-oxacalcitriol-3-hemiglutarate
• Synonyms: 22-oxacalcitriol-3-hemiglutarate
• CAS NO: 143773-34-6
• Molecular Formula: C₃₁H₄₈O₇
• Molecular Weight: 532.70862
• Mol File: 143773-34-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 687°C at 760 mmHg
• Flash Point: 215°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 7.54E-22mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 22-oxacalcitriol-3-hemiglutarate(CAS DataBase Reference)
• NIST Chemistry Reference: 22-oxacalcitriol-3-hemiglutarate(143773-34-6)
• EPA Substance Registry System: 22-oxacalcitriol-3-hemiglutarate(143773-34-6)

Safety Data

• Hazardous Substances Data: 143773-34-6(Hazardous Substances Data)

Usage

Properties

1. Synthetic derivative of calcitriol
2. Used as a potential treatment for conditions related to calcium metabolism
3. Higher potency and longer duration of action compared to calcitriol
4. Promising option for managing vitamin D deficiency and related disorders
5. Hemiglutarate form for improved absorption and bioavailability

Specific content

1. 22-oxacalcitriol-3-hemiglutarate is a synthetic derivative of calcitriol, a form of vitamin D.
2. It is used as a potential treatment for conditions related to calcium metabolism, such as osteoporosis and renal osteodystrophy.
3. This chemical has been shown to have a higher potency and longer duration of action compared to calcitriol.
4. It is a promising option for managing vitamin D deficiency and related disorders.
5. Its hemiglutarate form allows for improved absorption and bioavailability in the body, enhancing its effectiveness as a therapeutic agent for various bone and mineral disorders.

InChI:InChI=1/C31H48O7/c1-20-23(18-24(19-27(20)32)38-29(35)10-6-9-28(33)34)12-11-22-8-7-15-31(5)25(13-14-26(22)31)21(2)37-17-16-30(3,4)36/h11-12,21,24-27,32,36H,1,6-10,13-19H2,2-5H3,(H,33,34)/b22-11+,23-12+/t21-,24-,25?,26+,27-,31-/m0/s1

Upstream product

• 143773-32-4 1α,25-dihydroxy-22-oxacholesta-5,7-dien-3β-yl (2',2',2'-trichloroethylglutarate) 
• 103909-78-0 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(3-hydroxy-3-methylbutyloxy)pregna-5,7-diene 
• 142785-61-3 1α,3β-dihydroxy-20(S)-(3-hydroxy-3-methylbutyloxy)pregna-5,7-diene 
• 143773-33-5 (5Z,7E)-(1S,3R)-1,25-dihydroxy-22-oxa-9,10-secocholesta-5,7,10⁽¹⁹⁾-trien-3-yl (2',2',2'-trichloroethylglutarate) 

Relevant articles and documents

Production and specificity of anti-22-oxacalcitriol antisera

22-Oxacalcitriol 3-hemiglutarate, a haptenic derivative of 22-oxacalcitriol, was synthesized to obtain a specific antibody for use in radioimmunoassay. Three antisera were elicited in rabbits against the hapten conjugated with bovine serum albumin, and th