1437743-39-9

Basic information

• Product Name: (E)-3-(4-fluorophenyl)-1-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one
• Synonyms: (E)-3-(4-fluorophenyl)-1-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one
• CAS NO: 1437743-39-9
• Molecular Weight: 272.276
• Mol File: 1437743-39-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-3-(4-fluorophenyl)-1-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(4-fluorophenyl)-1-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one(1437743-39-9)
• EPA Substance Registry System: (E)-3-(4-fluorophenyl)-1-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one(1437743-39-9)

Safety Data

• Hazardous Substances Data: 1437743-39-9(Hazardous Substances Data)

Upstream product

• 493-33-4 1-(4-hydroxy-2-methoxy-phenyl)ethanone 
• 459-57-4 4-fluorobenzaldehyde 
• 65490-08-6 2-hydroxy-4-(methoxymethoxy)acetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 75227-17-7 1-(2-methoxy-4-(methoxymethoxy)phenyl)ethan-1-one 
• 108-46-3 recorcinol 
• 288856-48-4 1-(2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethanone 

Relevant articles and documents

Novel Nitric Oxide Donors of Phenylsulfonylfuroxan and 3-Benzyl Coumarin Derivatives as Potent Antitumor Agents

In this work, five new hybrids of phenylsulfonylfuroxan merging 3-benzyl coumarin and their seco-B-ring derivatives 2-6 were designed and synthesized. Among them, compound 3 showed the most potent antiproliferation activities with IC50 values range from 0.5 to 143 nM against nine drug-sensitive and four drug-resistant cancer cell lines. Preliminary pharmacologic studies showed that these compounds displayed lower toxicities than that of lead compound 1. Compound 3 obviously induced the early apoptosis and hardly affected the cell cycle of A2780, which was significantly different from compound 1. Especially, it gave 559- and 294-fold selectivity antiproliferation activity in P-gp overexpressed drug-resistant cancer cell lines MCF-7/ADR and KB-V compared to their drug-sensitive ones MCF-7 and KB, implying that compounds 2-6 might have an extra mechanism of anti-MDR-cancer with P-gp overexpression.

Chalcones, inhibitors for topoisomerase i and cathepsin B and L, as potential anti-cancer agents

In order to diversify the pharmacological activity of chalcones and extend the scaffold of topoisomerase and cathepsins B and L inhibitors, we have designed and synthesized total 18 chalcone compounds and tested their biological activity. In the topoisome