143782-18-7

Basic information

• Product Name: Benzonitrile, 4-isocyanato-2-(trifluoromethyl)-
• CAS NO: 143782-18-7
• Molecular Formula: C9H3F3N2O
• Molecular Weight: 212.131
• Mol File: 143782-18-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 268.2±40.0 °C(Predicted)
• Density: 1.31±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Benzonitrile, 4-isocyanato-2-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-isocyanato-2-(trifluoromethyl)-(143782-18-7)
• EPA Substance Registry System: Benzonitrile, 4-isocyanato-2-(trifluoromethyl)-(143782-18-7)

Safety Data

• Hazardous Substances Data: 143782-18-7(Hazardous Substances Data)

Usage

General Description

Benzonitrile, 4-isocyanato-2-(trifluoromethyl)- is a chemical compound with the molecular formula C9H5F3N2O. It is a clear, colorless liquid with a faint odor, and it is primarily used in the production of pharmaceuticals and agrochemicals. It is also used as a building block in the synthesis of other organic compounds, particularly in the creation of isocyanate-based polymers and resins. However, it is important to handle this chemical with caution as it is known to be a skin and eye irritant, and it can also be harmful if swallowed or inhaled. Proper safety measures and handling procedures should be followed when working with this chemical.

Upstream product

• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 
• 503-38-8 trichloromethyl chloroformate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 75-44-5 phosgene 
• 98-16-8 3-trifluoromethylaniline 
• 351-36-0 N-acetyl-3-trifluoromethylbenzenamine 
• 97760-99-1 C₁₀H₇F₃N₂O 
• 41513-05-7 N-(4-bromo-3-trifluoromethylphenyl)acetamide 

Downstream Products

• 143782-19-8 4-(4,4-Dimethyl-5-imino-2-oxo-1-imidazolidinyl)-2-trifluoromethyl-benzonitrile 
• 959690-11-0 4-[2,5-dioxo-4-(4-hydroxyphenyl)-4-methyl-3-(2-propynyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile 
• 959694-02-1 1,1-dimethylethyl 2,3-dihydro-5-methoxy-1-methyl-2-[[(4-cyano-3-trifluoromethylphenyl)-amino]carbonyl]-1H-isoindolecarboxylate 
• 959694-09-8 (R)-4-[2,5-dioxo-4-(4-methoxyphenyl)-4-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile 
• 512776-95-3 (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide 
• 90357-51-0 N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide 
• 316373-93-0 (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2,3-dihydroxy-2-methylpropanamide 
• 316373-94-1 (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2,3-dihydroxy-2-methylpropanamide 
• 627484-44-0 C₁₂H₁₀ClF₃N₂O₂ 
• 1215085-92-9 GLPG₀₄₉₂ 
• 1401226-62-7 (S)-(-)-4-[2,5-dioxo-4-(hydroxymethyl)-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile 
• 959691-74-8 (S)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile 
• 959691-73-7 (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile 
• 959694-11-2 (S)-4-[2,5-dioxo-4-(4-methoxyphenyl)-4-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile 

Relevant articles and documents

POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES

The current invention provides urea derivatives, in particular compounds having the core structure heteroaryl-NH-CO-NH-aryl-O- heteroaryl, for use in treating, ameliorating, delaying, curing and/ or preventing a disease or condition associated with muscle cells and/or satellite cells, such as Duchenne muscular dystrophy, Becker muscular dystrophy, cachexia or sarcopenia.

Novel pathway for the synthesis of arylpropionamide-derived selective androgen receptor modulator (SARM) metabolites of andarine and ostarine

O-Dephenylandarine and O-dephenylostarine, two SARM metabolites relevant for doping control analysis, were synthesized in their endogenous (S)-forms as well as in terms of their racemates. The enantiopure (S)-metabolites were obtained after six steps in 20% and 23% overall yield, the slightly modified racemic route provided the compounds in 28% and 31% total yield, respectively.

Heterocycle-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising them and use thereof

The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.