1437999-88-6

Basic information

• Product Name: N-(3-methoxybenzyl)benzisothiazol-3-one-2-amide
• Synonyms: N-(3-methoxybenzyl)benzisothiazol-3-one-2-amide
• CAS NO: 1437999-88-6
• Molecular Weight: 314.365
• Mol File: 1437999-88-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-methoxybenzyl)benzisothiazol-3-one-2-amide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-methoxybenzyl)benzisothiazol-3-one-2-amide(1437999-88-6)
• EPA Substance Registry System: N-(3-methoxybenzyl)benzisothiazol-3-one-2-amide(1437999-88-6)

Safety Data

• Hazardous Substances Data: 1437999-88-6(Hazardous Substances Data)

Upstream product

• 5071-96-5 3-METHOXYBENZYLAMINE 
• 2634-33-5 1,2-benzisothiazolin-3-one 
• 57198-56-8 1-(isocyanatomethyl)-3-methoxybenzene 

Relevant articles and documents

Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors

A number of 1,2-benzisothiazol-3-one derivatives were prepared through structural modification of the original compound from high-throughput screening. Some analogues (e.g., 6b, 6r, 6s and 6w) were identified as novel and potent caspase inhibitors with IC50 of nanomolar. Structure-activity relationship (SAR) studies for caspase-3 inhibition were evaluated in vitro. Molecular modeling studies provided further insight into the interaction of this class of compounds with activated caspase-3. The present small molecule caspase-3 inhibitor with novel structures different from structures of known caspase inhibitors revealed a new direction for therapeutic strategies directed against diseases involving abnormally up-regulated apoptosis.