1438000-02-2

Basic information

• Product Name: N-(2-fluorobenzyl)benzisothiazol-3-one-2-amide
• Synonyms: N-(2-fluorobenzyl)benzisothiazol-3-one-2-amide
• CAS NO: 1438000-02-2
• Molecular Weight: 302.329
• Mol File: 1438000-02-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-fluorobenzyl)benzisothiazol-3-one-2-amide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-fluorobenzyl)benzisothiazol-3-one-2-amide(1438000-02-2)
• EPA Substance Registry System: N-(2-fluorobenzyl)benzisothiazol-3-one-2-amide(1438000-02-2)

Safety Data

• Hazardous Substances Data: 1438000-02-2(Hazardous Substances Data)

Upstream product

• 2634-33-5 1,2-benzisothiazolin-3-one 
• 132740-44-4 2-fluorobenzyl isocyanate 
• 89-99-6 2-fluorobenzylamine 

Relevant articles and documents

Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors

A number of 1,2-benzisothiazol-3-one derivatives were prepared through structural modification of the original compound from high-throughput screening. Some analogues (e.g., 6b, 6r, 6s and 6w) were identified as novel and potent caspase inhibitors with IC50 of nanomolar. Structure-activity relationship (SAR) studies for caspase-3 inhibition were evaluated in vitro. Molecular modeling studies provided further insight into the interaction of this class of compounds with activated caspase-3. The present small molecule caspase-3 inhibitor with novel structures different from structures of known caspase inhibitors revealed a new direction for therapeutic strategies directed against diseases involving abnormally up-regulated apoptosis.