143823-74-9Relevant articles and documents
A FACILE SYNTHESIS OF 9-NOR-9-HYDROXYHEXAHYDROCANNABINOL VIA INTRAMOLECULAR REVERSE ELECTRON DEMAND DIELS-ALDER CYCLIZATION
Lu, Zhan Guo,Inoue, Seiichi
, p. 1107 - 1117 (2007/10/02)
A simple and efficient new synthesis of 9-nor-9-hydroxyhexahydrocannabinol is achieved, through the intramolecular cycloaddition of an o-quinonemethide which is generated from 2-(1-hydroxy-3-methoxymethoxy-7-methyl-6-octenyl)-1,3-bis(O-methoxymethyl)olivetol (12b), which in turn is prepared by reaction of the lithiated olivetol bis(methoxymethyl)ether with 3-methoxymethoxy-7-methyl-6-octenal (9).