143839-72-9

Basic information

• Product Name: Pyrazine, 2-chloro-3-(1-methylpropyl)-, (S)-
• CAS NO: 143839-72-9
• Molecular Formula: C8H11ClN2
• Molecular Weight: 170.642
• Mol File: 143839-72-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyrazine, 2-chloro-3-(1-methylpropyl)-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazine, 2-chloro-3-(1-methylpropyl)-, (S)-(143839-72-9)
• EPA Substance Registry System: Pyrazine, 2-chloro-3-(1-methylpropyl)-, (S)-(143839-72-9)

Safety Data

• Hazardous Substances Data: 143839-72-9(Hazardous Substances Data)

Upstream product

• 26433-54-5 isoleucine amide 
• 143785-43-7 3-sec-butyl-2(1H)-pyrazinone 

Downstream Products

• 24168-70-5 2-(methoxy)-3-(1-methylpropyl)pyrazine 

Relevant articles and documents

New insights into the synthesis and characterization of 2-methoxy-3-alkylpyrazines and their deuterated isotopologues

A previously described synthetic route for preparation of 2-methoxy-3-alkylprazines (MPs) based on condensation of glyoxal with an α-amino acid amide, followed by methylation with iodomethane yields 3-alkyl-1-methyl-1H-pyrazin-2-ones (N-methyl derivatives), rather than the designated 2-methoxy-3-alkylpyrazines (O-methyl derivatives). Despite similar nuclear magnetic resonance and mass spectral properties, gas chromatographic (GC) retention indices differ significantly, indicating chemical difference. With the example of 3-sec-butyl-1-methyl-1H-pyrazin-2-one and its 3-sec-butyl-1-[2H3]methyl-1H-pyrazin-2-one isotopologue, the position of the methyl group introduced could be assigned unambiguously, using heteronuclear multiple bond correlation (HMBC) NMR experiments. For future characterization, the spectroscopic (NMR, EI+MS) as well as GC retention index data on two stationary phases of the most aroma relevant MPs and their deuterated isotopologues are summarized. Copyright