1438428-70-6

Basic information

• Product Name: C₂₁H₁₈N₄OS
• CAS NO: 1438428-70-6
• Molecular Weight: 374.466
• Mol File: 1438428-70-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₈N₄OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₈N₄OS(1438428-70-6)
• EPA Substance Registry System: C₂₁H₁₈N₄OS(1438428-70-6)

Safety Data

• Hazardous Substances Data: 1438428-70-6(Hazardous Substances Data)

Upstream product

• 50-66-8 6-methylthiopurine 
• 614-47-1 1,3-diphenyl-propen-3-one 

Relevant articles and documents

Organocatalytic enantioselective aza-Michael addition of purine bases to α,β-unsaturated ketones

The first organocatalytic enantioselective aza-Michael addition of purine bases to α,β-unsaturated ketones has been developed, affording Michael adducts in moderate to high yields (up to 96% yield) and high to excellent enantioselectivities (up to >99% ee). A wide range of α,β-unsaturated ketones including aliphatic and aromatic enones are tolerated in this process, generally demonstrating good reactivity, regioselectivity and enantioselectivity. The aromatic α,β-unsaturated ketones showing quite low reactivity in the reported catalytic systems, were first successfully employed as Michael acceptors in this transformation, yielding high enantioselectivities (up to 94% ee). The utility of this method was also applied for the synthesis of enantioenriched non-natural nucleoside analogues with potential biological activities. Copyright