143868-89-7Relevant articles and documents
Preparation method of (R)-4-propyl-dihydrofuran-2-one and preparation intermediate of (R)-4-propyl-dihydrofuran-2-one
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Paragraph 0047-0048, (2020/07/14)
The invention discloses a preparation method of (R)-4-propyl-dihydrofuran-2-one and a preparation intermediate of (R)-4-propyl-dihydrofuran-2-one. The preparation method of the intermediate comprisesthe following steps: (1) in the presence of an acid or an alkali, carrying out hydrolysis reaction on a compound I to obtain a compound II or a salt thereof; and (2) carrying out reduction reaction onthe compound II or the salt thereof and a reducing agent to obtain a compound III. According to the preparation route disclosed by the invention, the use of flammable and explosive reaction reagentsin the existing route is avoided; reagents which are low in cost and easy to obtain in industry are used; compared with the prior art, the method has the advantages of low cost, safety in production,realization of the purification and the separation of the intermediate by using the acid-base property of the compound and adopting the mode of adjusting the pH value of the system in the reaction process and the post-treatment operation, avoiding of recrystallization, filtration and other tedious operation modes, simplification of the operation, and suitableness for industrial large-scale production.
A (R)-4 - propyl - dihydrofuran -2 - ketone
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Paragraph 0076-0085, (2019/04/10)
The invention discloses a process for preparing (R)- 4 - propyl - dihydrofuran - 2 - one method, the key intermediate type B compound, type C compound and its preparation method; (R)- 4 - propyl - dihydrofuran - 2 - one of the preparation method of the operability of the strong, is suitable for industrial production.
New synthesis method of brivaracetam
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Paragraph 0057; 0058; 0059; 0060, (2017/10/13)
The invention provides a synthesis method of brivaracetam. The method adopts cheap and easily available pentanoic acid or valeryl halide as an initial raw material, and provides a brand new synthesis route of a brivaracetam medicine, and the whole reaction route has a high total yield. The method has the advantages of high productivity, low cost, and suitableness for large-scale industrial production.