143886-50-4

Basic information

• Product Name: 1H-Imidazole-2-methanol, 1-propyl-
• Synonyms: F2101-0174;2-hydroxymethyl-1-propylimidazole;1H-Imidazole-2-methanol,1-propyl;2-hydroxymethyl-N-propylimidazole;1-n-propylimidazole-2-methanol;1-Propyl-2-hydroxymethylimidazole
• CAS NO: 143886-50-4
• Molecular Formula: C7H12N2O
• Molecular Weight: 140.185
• Mol File: 143886-50-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 288.3±23.0 °C(Predicted)
• Density: 1.09±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Imidazole-2-methanol, 1-propyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-2-methanol, 1-propyl-(143886-50-4)
• EPA Substance Registry System: 1H-Imidazole-2-methanol, 1-propyl-(143886-50-4)

Safety Data

• Hazardous Substances Data: 143886-50-4(Hazardous Substances Data)

Usage

General Description

1H-Imidazole-2-methanol, 1-propyl- is a chemical compound with the molecular formula C7H12N2O. It is an imidazole derivative with a propyl group attached to the nitrogen atom. 1H-Imidazole-2-methanol, 1-propyl- is known for its antimicrobial and antifungal properties, and it is commonly used in pharmaceuticals and personal care products. It is also utilized in the synthesis of various drugs and as a reagent in organic chemistry reactions. Additionally, 1H-Imidazole-2-methanol, 1-propyl- has been studied for its potential applications in the treatment of certain medical conditions, making it a compound of interest for researchers in the pharmaceutical and biomedical fields.

Upstream product

• 161500-05-6 1-propyl-1H-imidazole-2-carbaldehyde 

Downstream Products

• 497852-92-3 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-propyl-1H-imidazol-2-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 497853-81-3 4-{[(1-propyl-1H-imidazol-5-yl)methyl]sulfanyl}aniline 

Relevant articles and documents

Syntheses, protonation constants and antimicrobial activity of 2-substituted N-alkylimidazole derivatives

A series of N-alkylimidazole-2-carboxylic acid, N-alkylimidazole-2- carboxaldehyde and N-alkylimidazole-2-methanol derivatives [alkyl = benzyl, methyl, ethyl, propyl, butyl, heptyl, octyl and decyl] have been synthesized and the protonation constants determined. The antimicrobial properties of the compounds were tested against Gram-negative (Escherichi coli), Gram-positive (Staphylococcus aureus & Bacillus subtilis subsp. spizizenii) bacterial strains and yeast (C. albicans). Both the disk diffusion and broth microdilution methods for testing the antimicrobial activity showed that N-alkylation of imidazole with longer alkyl chains and the substitution with low pKa group at 2-position resulted in enhanced antimicrobial activity. Particularly, the N-alkylimidazole-2-carboxylic acids exhibited the best antimicrobial activity due to the low pKa of the carboxylic acid moiety. Generally, all the N-alkylimidazole derivatives were most active against the Gram-positive bacteria [S. aureus (MIC = 5-160 μg mL-1) and B. subtilis subsp. spizizenii (5-20 μg mL-1)], with the latter more susceptible. All the compounds showed poor antimicrobial activity against both Gram-negative (E. coli, MIC = 0.15 to >2500 μg mL-1) bacteria and all the compounds were inactive against the yeast (Candida albicans).

BENZAZEPINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

The present invention provides a novel benzazepine derivative represented by formula : wherein, R1 is a 5- or 6-membered aromatic ring, R2 is lower alkyl group, etc., Y is an optionally substituted imino group, ring A and ring B are independently an optionally substituted aromatic ring, W is formula -W1-X2-W2- (W1 and W2 are independently S(O)m1 (m1 is 0, 1 or 2), etc., and X2 is an optionally substituted alkylene groupetc. ), a preparation method and use thereof.